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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Efficacy of single-dose diethylcarbamazine compared with diethylcarbamazine combined with albendazole against Wuchereria bancrofti infection in Papua New Guinea.
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Efficacy of single-dose diethylcarbamazine compared with diethylcarbamazine combined with albendazole against Wuchereria bancrofti infection in Papua New Guinea.

机译：单剂量二乙基卡巴他嗪与二乙基卡巴他嗪联合阿苯达唑相比在巴布亚新几内亚对班氏支原体感染的疗效。

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摘要

The efficacy of diethylcarbamazine alone was compared with diethylcarbamazine plus albendazole in residents of an island in Papua New Guinea endemic for Wuchereria bancrofti. There was no statistically significant difference between the two drug regimens in decreasing the microfilaria positive rate at 12 and 24 months after a single-dose treatment with either regimen, e.g., 50.0% clearance of microfilaria at 24 months for diethylcarbamazine alone versus 65.7% clearance of microfilaria for diethylcarbamazine plus albendazole (P > 0.05). In contrast, diethylcarbamazine plus albendazole resulted in a significant decrease in Og4C3 antigen prevalence (17%; P = 0.003) at 24 months whereas diethylcarbamazine did not (10%; P = 0.564). These data showed no statistically significant difference in the efficacy of the two drug regimens in lowering the microfilaria reservoir, but they support the use of diethylcarbamazine combined with albendazole in mass treatment programs on the basis of greater activity against adult worms.
机译：在巴布亚新几内亚地方性地方性无荚果（Wuchereria bancrofti）的居民中，仅将二乙基卡巴嗪与二乙基卡巴嗪加阿苯达唑的疗效进行了比较。两种药物方案在单剂治疗后12和24个月降低微丝aria阳性率之间无统计学差异，例如，仅二乙基卡巴他嗪在24个月时微丝aria清除率为50.0％，而二乙基卡巴他嗪的65.7％清除率。二乙基卡巴嗪加阿苯达唑的微丝虫病（P> 0.05）。相反，二乙基卡巴马嗪加阿苯达唑在24个月时导致Og4C3抗原发生率显着降低（17％; P = 0.003），而二乙基卡巴马嗪则没有（10％; P = 0.564）。这些数据显示两种药物方案在降低微丝aria贮库的功效上没有统计学上的显着差异，但它们基于对成虫的更高活性，支持在大规模治疗方案中使用二乙基卡巴他嗪和阿苯达唑。

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