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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Pediatric diarrhea in southern Ghana: etiology and association with intestinal inflammation and malnutrition.
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Pediatric diarrhea in southern Ghana: etiology and association with intestinal inflammation and malnutrition.

机译：加纳南部的小儿腹泻：病因及与肠道炎症和营养不良有关。

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摘要

Diarrhea is a major public health problem that affects the development of children. Anthropometric data were collected from 274 children with (N = 170) and without (N = 104) diarrhea. Stool specimens were analyzed by conventional culture, polymerase chain reaction for enteroaggregative Escherichia coli (EAEC), Shigella, Cryptosporidium, Entamoeba, and Giardia species, and by enzyme-linked immunosorbent assay for fecal lactoferrin levels. About 50% of the study population was mildly to severely malnourished. Fecal lactoferrin levels were higher in children with diarrhea (P = 0.019). Children who had EAEC infection, with or without diarrhea, had high mean lactoferrin levels regardless of nutritional status. The EAEC and Cryptosporidium were associated with diarrhea (P = 0.048 and 0.011, respectively), and malnourished children who had diarrhea were often co-infected with both Cryptosporidium and EAEC. In conclusion, the use of DNA-biomarkers revealed that EAEC and Cryptosporidium were common intestinal pathogens in Accra, and that elevated lactoferrin was associated with diarrhea in this group of children.
机译：腹泻是影响儿童发育的主要公共卫生问题。从274名（N = 170）没有腹泻（N = 104）的儿童中收集了人体测量数据。通过常规培养，肠聚合性大肠杆菌（EAEC），志贺氏菌，隐孢子虫，Entamoeba和Giardia种的聚合酶链反应，以及粪便中乳铁蛋白水平的酶联免疫吸附分析，分析了粪便标本。约50％的研究人群轻度至严重营养不良。腹泻儿童的粪便中乳铁蛋白水平较高（P = 0.019）。无论营养状况如何，患有EAEC感染，有或没有腹泻的儿童均具有较高的平均乳铁蛋白水平。 EAEC和隐孢子虫病与腹泻有关（分别为P = 0.048和0.011），营养不良的腹泻儿童通常会同时感染隐孢子虫和EAEC。总之，使用DNA生物标记揭示了EAEC和隐孢子虫是阿克拉的常见肠道病原体，而乳铁蛋白升高与该组儿童的腹泻有关。

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