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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Serum levels of erythropoietin in acute Plasmodium falciparum malaria.
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Serum levels of erythropoietin in acute Plasmodium falciparum malaria.

机译:急性恶性疟原虫疟疾中的促红细胞生成素的血清水平。

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摘要

The pathophysiologic backgrounds of anemia in malaria are complex and multifactorial. The purpose of the present study was to measure serum concentrations of erythropoietin (EPO) and to evaluate the adequacy of EPO production in patients suffering from acute Plasmodium falciparum malaria. Fifteen patients with complicated malaria were included in the study. Serum samples were taken on the day of admission, and days 7, 14, 21 and 28. Serum EPO concentrations were measured using an enzyme-linked immunosorbent assay. The median serum EPO concentration was 15.6 mU/ml on the day of admission (range 0.5-567) mU/ml, 10.6 mU/ml (1.2-863) on day 7, 11.8 mU/ml (0.5-72.8) on day 14, 10 mU/ml (0.5-74.6) on day 21, and 8.3 mU/ml (2.2-61.6) on day 28. Inadequate EPO production was found in 46.6% of the patients on the day of admission, which increased to 67% and 68% on days 7 and 14, and reached a maximum of 80% on day 21. Almost 54% of patients had inadequate EPO production on day 28. Our data indicate inadequate EPO production in patients suffering from acute P. falciparum malaria, which might contribute to the prolonged anemia observed in these patients.
机译:疟疾贫血的病理生理背景是复杂和多因素的。本研究的目的是测量血清中促红细胞生成素(EPO)的浓度,并评估急性恶性疟原虫疟疾患者中EPO产生的适当性。本研究纳入了15例复杂的疟疾患者。在入院当天以及第7、14、21和28天采集血清样品。使用酶联免疫吸附测定法测量血清EPO浓度。入院当天的血清EPO浓度中位数为15.6 mU / ml(范围0.5-567)mU / ml,第7天为10.6 mU / ml(1.2-863),第14天为11.8 mU / ml(0.5-72.8) ,第21天的10 mU / ml(0.5-74.6)和第28天的8.3 mU / ml(2.2-61.6)。入院当天46.6%的患者发现EPO产生不足,增至67%在第7天和第14天占68%,在第21天达到最高80%。在第28天,几乎54%的患者EPO产生不足。我们的数据表明,患有恶性疟原虫疟疾的患者的EPO产生不足。可能导致这些患者长期贫血。

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