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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Helminth infections are associated with protection from cerebral malaria and increased nitrogen derivatives concentrations in Thailand.
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Helminth infections are associated with protection from cerebral malaria and increased nitrogen derivatives concentrations in Thailand.

机译：在泰国，蠕虫感染与预防脑疟疾和增加氮衍生物浓度有关。

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摘要

Following a study showing an association between Ascaris and protection from cerebral malaria, we hypothesized helminths may have induced protection through immunoglobulin E (IgE) and the CD23/NO pathway. We compared the prevalence of helminth infections in 67 cerebral malaria patients and 217 hyperparasitemic controls with no complications. For 24 cerebral malaria cases and 56 controls, we compared reactive nitrogen intermediates (RNI) concentrations and their correlations to total IgE and sCD23 concentrations in helminth-infected and noninfected patients. We observed a dose-dependent association between helminth infections and protection from cerebral malaria (adjusted odds ratio [OR] = 0.36, 95% CI = 0.19-0.7, P = 0.002, linear trend P = 0.0007). Helminth-infected controls had higher RNI concentrations than those without helminths: 72 OD +/- 19 SD and 57 OD +/- 20 SD, respectively (P = 0.006). Logistic regression, including interaction terms between RNI and sCD23, showed that an increase of RNI could be both protective and pathogenic depending on the concentration of sCD23. Helminths increasing both the CD23 receptor and its ligand may have a role in the establishment of malaria tolerance through the CD23/NO pathway.
机译：在一项研究表明A虫病与脑部疟疾保护之间存在关联之后，我们假设蠕虫可能通过免疫球蛋白E（IgE）和CD23 / NO途径诱导了保护作用。我们比较了67例脑疟疾患者和217例无并发症的高寄生虫控制者的蠕虫感染患病率。对于24例脑疟疾病例和56例对照，我们比较了蠕虫感染和未感染患者的活性氮中间体（RNI）浓度及其与总IgE和sCD23浓度的相关性。我们观察到蠕虫感染与对脑疟疾的保护之间存在剂量依赖性关系（调整后的优势比[OR] = 0.36，95％CI = 0.19-0.7，P = 0.002，线性趋势P = 0.0007）。感染蠕虫的对照组的RNI浓度高于没有蠕虫的对照组：分别为72 OD +/- 19 SD和57 OD +/- 20 SD（P = 0.006）。 Logistic回归分析（包括RNI与sCD23之间的相互作用项）表明，根据sCD23的浓度，RNI的升高可能既具有保护性又具有致病性。增加CD23受体及其配体的蠕虫可能在通过CD23 / NO途径建立疟疾耐受性中起作用。

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