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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1.
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Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1.

机译：简短报告：评价曼氏血吸虫和人类免疫缺陷病毒1共同感染​​者的肝纤维化。

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摘要

To investigate whether infection with human immunodeficiency virus 1 (HIV-1) affects fibrosis development in patients infected with Schistosoma mansoni, we evaluated schistosomiasis-induced pathology in the livers of Kenyan patients co-infected with HIV-1. Compared with persons with schistosomiasis alone (n = 58), there were no significant differences in distribution of ultrasound-detectable pathology in persons with HIV-1 co-infection (n = 23). Similarly, serum aspartate aminotransferase levels were not significantly different in HIV-1+ individuals. Hepatic fibrosis was associated with significantly decreased CD4+ T cell counts, even in the absence of HIV-1 infection. These data suggest that HIV-1 co-infection does not significantly alter the proportion of patients experiencing schistosomiasis-induced fibrosis, but pathology associated with S. mansoni infections leads to CD4+ T cell reductions and thereby may exacerbate the effects of HIV-1 in co-infected individuals.
机译：为了调查人类免疫缺陷病毒1（HIV-1）的感染是否影响曼氏血吸虫感染患者的纤维化发展，我们评估了血吸虫病诱发的肯尼亚感染HIV-1的患者肝脏病理学变化。与仅血吸虫病患者相比（n = 58），在HIV-1合并感染者中超声可检测的病理分布没有显着差异（n = 23）。同样，HIV-1 +患者的血清天冬氨酸转氨酶水平也无显着差异。肝纤维化与CD4 + T细胞计数显着降低有关，即使没有HIV-1感染也是如此。这些数据表明，HIV-1合并感染不会显着改变经历血吸虫病诱导的纤维化的患者比例，但与曼氏沙门氏菌感染相关的病理会导致CD4 + T细胞减少，从而可能加剧HIV-1在感染中的作用感染的个体。

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