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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Seasonal fluctuation of antibody levels to Plasmodium falciparum parasitized red blood cell-associated antigens in two Senegalese villages with different transmission conditions.
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Seasonal fluctuation of antibody levels to Plasmodium falciparum parasitized red blood cell-associated antigens in two Senegalese villages with different transmission conditions.

机译：在两个传播条件不同的塞内加尔村庄，针对恶性疟原虫的抗体水平的季节性波动寄生了红细胞相关抗原。

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摘要

The recombinant R23, PfEB200, and GST-5 antigens derive from conserved antigens associated with the Plasmodium falciparum-infected erythrocyte membrane. They were identified as targets of protective antibodies in the Saimiri sciureus model. We have assessed here the humoral response to these antigens in humans. Cross-sectional surveys were conducted in two Senegalese villages with different levels of endemicity. The prevalence of specific IgG and IgM was similar and influenced by age in both localities. The anti-R23 antibodies decreased after the rainy season, particularly in the children less than ten years old. The anti-PfEB200 response did not show significant seasonal variation. The anti-GST-5 response increased in both the less-than 10-year-old and the greater-than 10-year-old groups after the rainy season in Dielmo, but only in the Ndiop villagers who were more than 10-years-old. Thus, antigen-specific seasonal variations of antibody levels were influenced differently by age in both villages. The isotype distribution was antigen-specific and differed for both seasons.
机译：重组R23，PfEB200和GST-5抗原源自与恶性疟原虫感染的红细胞膜相关的保守抗原。在Saimiri sciureus模型中，它们被确定为保护性抗体的靶标。我们在这里评估了人类对这些抗原的体液反应。横断面调查是在塞内加尔两个地方流行程度不同的村庄进行的。特异性IgG和IgM的患病率相似，并且受两个地区年龄的影响。抗R23抗体在雨季后减少，尤其是在十岁以下的儿童中。抗PfEB200反应未显示明显的季节性变化。在Dielmo雨季之后，年龄不足10岁的人群和年龄大于10岁的人群中的抗GST-5应答均增加，但只有超过10岁的Ndiop村民才提高-旧。因此，在两个村庄中，抗体水平的抗原特异性季节性变化受年龄的影响不同。同种型分布是抗原特异性的，并且两个季节都不同。

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