...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea.
【24h】

The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea.

机译：补锌对恶性疟原虫发病率的影响：巴布亚新几内亚学龄前儿童的一项随机试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Zinc is crucial for normal immune function and can reduce morbidity from multiple infectious diseases. To determine the influence of zinc on malaria morbidity we conducted a randomized placebo-controlled trial of daily zinc supplementation in children residing in a malaria endemic region of Papua New Guinea. A total of 274 preschool children aged 6 to 60 months were given 10 mg elemental zinc (n = 136) or placebo (n = 138) for 6 days a week for 46 weeks. Slide-confirmed malaria episodes were detected by surveillance of cases self-reporting to a local health center. Cross-sectional surveys were conducted at the beginning, middle, and end of the study to assess infection rates, parasite density, spleen enlargement, and hemoglobin levels. Zinc supplementation resulted in a 38% (95% CI 3-60, P = 0.037) reduction in Plasmodium falciparum health center-based episodes, defined as parasitemia > or = 9200 parasites/microl with axial temperature > or = 37.5 degreesC or reported fever. Episodes accompanied by any parasitemia were also reduced by 38% (95% CI 5-60, P = 0.028), and episodes with parasitemia > or = 100,000/microl were reduced by 69% (95% CI 25-87, P = 0.009). There was no evidence of the effects of zinc on Plasmodium vivax morbidity or on health center attendance for causes other than P. falciparum. Zinc had no consistent effect on cross-sectional malariometric indices. Although P. falciparum prevalence tended to be lower at the end of the study in children given the placebo, such changes were absent at the mid-study survey. These results suggest that improved dietary zinc intake may reduce morbidity due to P. falciparum.
机译：锌对于正常的免疫功能至关重要，并且可以减少多种传染病的发病率。为了确定锌对疟疾发病率的影响，我们对居住在巴布亚新几内亚疟疾流行地区的儿童进行了每日补充锌的随机安慰剂对照试验。总共向274名6至60个月大的学龄前儿童提供10 mg元素锌（n = 136）或安慰剂（n = 138），每周6天，共46周。通过监视自我报告给当地卫生中心的病例，可以检测到幻灯片确诊的疟疾发作。在研究的开始，中期和结束时进行横断面调查，以评估感染率，寄生虫密度，脾肿大和血红蛋白水平。补充锌可使恶性疟原虫健康中心发作减少38％（95％CI 3-60，P = 0.037），定义为寄生虫血症>或= 9200寄生虫/每微升，轴向温度>或= 37.5摄氏度或发烧。伴随任何寄生虫病的发作也减少了38％（95％CI 5-60，P = 0.028），寄生虫病>或= 100,000 / microl的发作减少了69％（95％CI 25-87，P = 0.009） ）。除恶性疟原虫外，没有证据表明锌对间日疟原虫发病率或健康中心就诊有影响。锌对横截面测疟指标没有一致的影响。尽管在研究结束时使用安慰剂的儿童恶性疟原虫的患病率较低，但在中期研究中却没有这种变化。这些结果表明，改善饮食中锌的摄入量可以减少恶性疟原虫引起的发病率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号