...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Antibody-mediated in vitro growth inhibition of field isolates of Plasmodium falciparum from asymptomatic children in Burkina Faso.
【24h】

Antibody-mediated in vitro growth inhibition of field isolates of Plasmodium falciparum from asymptomatic children in Burkina Faso.

机译：布基纳法索无症状儿童恶性疟原虫野外分离株的抗体介导的体外生长抑制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antibody-mediated inhibition of Plasmodium falciparum parasites in vitro reflects the potential parasite-neutralizing activity of the antibodies in vivo. In this study, immunoglobulins and P. falciparum isolates were collected from children with asymptomatic malaria in Burkina Faso. We demonstrate a significantly lower in vitro growth inhibitory activity against the P. falciparum field isolates by autologous host immunoglobulin compared with that of immunoglobulin from other individuals. To gain further insight to possible mechanisms for the diverse sensitivity observed, analyses of consecutive isolates taken 14 days apart were performed with regard to polymerase chain reaction-based genotyping and sensitivity to growth inhibition in vitro. All the asymptomatic infections were composed of multiple, genotypically distinct parasite clones, and at least one new parasite clone appeared in most of the day 14 isolates compared with the corresponding day 0 isolates. Apparently persisting parasite clones, present in both the day 0 and day 14 isolates from the same person, were also frequently observed. The day 14 isolates were more effectively inhibited by autologous day 14 immunoglobulin than by the corresponding day 0 immunoglobulin in 57% of the cases. However, the frequent presence of persisting parasite clones in asymptomatic children indicates that the parasite may develop a relative resistance to neutralizing immune responses.
机译：体外对抗体介导的恶性疟原虫寄生虫的抑制反映了体内抗体潜在的寄生虫中和活性。在这项研究中，从布基纳法索的无症状疟疾儿童中收集了免疫球蛋白和恶性疟原虫分离株。我们证明自体宿主免疫球蛋白对恶性疟原虫分离株的体外生长抑制活性明显低于其他个体的免疫球蛋白。为了进一步了解观察到的多种敏感性的可能机制，对基于聚合酶链反应的基因分型和体外生长抑制敏感性进行了间隔14天的连续分离株分析。所有无症状感染均由多个在基因型上不同的寄生虫克隆组成，与第0天的分离株相比，在第14天的大多数分离株中至少出现了一个新的寄生虫克隆。还经常观察到存在于同一人的第0天和第14天分离株中的明显存在的寄生虫克隆。在57％的病例中，第14天的分离物被自体第14天的免疫球蛋白抑制得比相应的第0天的免疫球蛋白更有效。但是，无症状儿童中寄生虫克隆的频繁出现表明该寄生虫可能对中和免疫反应产生相对抗性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号