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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Molecular epidemiology of human immunodeficiency virus-infected individuals in Medellin, Colombia.
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Molecular epidemiology of human immunodeficiency virus-infected individuals in Medellin, Colombia.

机译：哥伦比亚麦德林市人类免疫缺陷病毒感染者的分子流行病学。

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摘要

To study the molecular epidemiology of human immunodeficiency virus type 1 (HIV-1) strains in Medellin, Colombia, 115 HIV-1-positive individuals who were recruited from an HIV outpatient hospital (Universitario San Vicente de Paul) during the period from July 2001 to January 2002 were genotyped. All samples were analyzed by envelope heteroduplex mobility assay and found to be subtype B. Twenty-four samples were randomly selected for sequencing of the protease and the reverse transcriptase regions; all isolates were found to be subtype B. Phylogenetic analysis of seven nearly full-length genomes showed that all samples were subtype B. This study shows that the HIV epidemic in Colombia continues to be dominated by the subtype B virus. The predominance of subtype B genotypes of HIV-1 strains in Medellin resembles what is seen in the nearby countries of Peru, Ecuador, and Venezuela.
机译：为了研究哥伦比亚麦德林市人类免疫缺陷病毒1型（HIV-1）菌株的分子流行病学，从2001年7月开始，他们从HIV门诊医院（Universitario San Vicente de Paul）招募了115名HIV-1阳性患者到2002年1月进行基因分型。通过包膜异源双链迁移率分析法分析所有样品，发现它们是B亚型。随机选择24个样品用于蛋白酶和逆转录酶区域的测序。所有分离物均被发现为B型。对七个近乎全长基因组的系统进化分析表明，所有样品均为B型。这项研究表明，哥伦比亚的HIV流行继续由B型病毒主导。在麦德林，HIV-1菌株的B型亚型占主导地位，与附近的秘鲁，厄瓜多尔和委内瑞拉国家类似。

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