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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >CD4+ T-cell counts, CD4+/CD8+ T-cell count ratios, and antibody levels in migrant fishermen infected with Schistosoma japonicum in the Dongting Lake, China.
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CD4+ T-cell counts, CD4+/CD8+ T-cell count ratios, and antibody levels in migrant fishermen infected with Schistosoma japonicum in the Dongting Lake, China.

机译：中国洞庭湖感染日本血吸虫的移民渔民的CD4 + T细胞计数，CD4 + / CD8 + T细胞计数比率和抗体水平。

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摘要

In this study, CD4(+) and CD8(+) T cells and antibody levels were measured in 94 migrant fishermen infected with Schistosoma japonicum from Dongting Lake, China. Prevalence among these fishermen was high (63.8%), with a mean infection intensity of 61.4 +/- 3.8 epg, and included a high proportion of individuals (39.4%) with substantial parenchymal fibrosis (stages > or = 2/3). The CD4(+)/CD8(+) ratio in men (1.34 +/- 0.11) was significantly lower than that of women (1.58 +/- 0.15). CD4(+) T cells and the ratio of CD4(+)/CD8(+) were significantly decreased both in subjects infected with S. japonicum and those with parenchymal fibrosis. However, levels of total IgA, IgM, and anti-schistosome egg antigen IgG correlated positively with infection intensity and pathologic lesion number. These results suggest an imbalance between cell-mediated and humoral immunity in these fishermen, the precise cause of which remains undetermined.
机译：在这项研究中，对94名来自中国洞庭湖的日本血吸虫感染的移民渔民测量了CD4（+）和CD8（+）T细胞以及抗体水平。这些渔民中的患病率很高（63.8％），平均感染强度为61.4 +/- 3.8 epg，包括大量实质性纤维化（阶段≥2/3）的个体（39.4％）。男性的CD4（+）/ CD8（+）比率（1.34 +/- 0.11）明显低于女性（1.58 +/- 0.15）。在感染日本血吸虫和实质纤维化的受试者中，CD4（+）T细胞和CD4（+）/ CD8（+）的比例均显着降低。但是，总IgA，IgM和抗血吸虫卵抗原IgG的水平与感染强度和病理病变数目呈正相关。这些结果表明，在这些渔民中，细胞介导的免疫和体液免疫之间的失衡，其确切原因尚不确定。

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