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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >An animal model for studying the pathogenesis of chikungunya virus infection.
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An animal model for studying the pathogenesis of chikungunya virus infection.

机译：研究基孔肯雅病毒感染发病机理的动物模型。

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摘要

Newborn and 14-day-old mice inoculated subcutaneously with chikungunya virus (CHIKV) developed lethargy, difficulty walking, dragging of hind limbs, and reduced weight gain within 7-10 days after infection (PI). During the initial 6-7 days PI, the animals had viremia; high levels (10(6)-10(8) PFU) of CHIKV were also present in leg muscle. The virus persisted in muscle for several days after viremia disappeared. The major histopathologic changes were in skeletal muscle, which were focal necrosis and inflammation, followed by fibrosis and dystrophic calcification. Some mice also showed dystrophic calcification in the joint cartilage, but there were few deaths, and most of the animals eventually recovered. CHIKV antigen was shown by immunohistochemistry in the muscle for several weeks after infection. Based on the clinical and pathologic similarities with CHIKV infection in humans, young ICR and CD-1 mice offer a useful and realistic model for further study of the pathogenesis and treatment of CHIKV infection.
机译：皮下接种基孔肯雅病毒（CHIKV）的新生和14日龄小鼠在感染（PI）后7到10天内会出现嗜睡，行走困难，后肢拖拉和体重增加减少的现象。在接种后的最初6到7天，动物出现病毒血症;高水平（10（6）-10（8）PFU）的CHIKV也存在于腿部肌肉中。病毒血症消失后，病毒在肌肉中持续存在几天。主要的组织病理学改变是骨骼肌，即局灶性坏死和炎症，其次是纤维化和营养不良性钙化。一些小鼠的关节软骨也显示营养不良性钙化，但死亡很少，大多数动物最终得以康复。感染后数周，通过免疫组织化学在肌肉中显示了CHIKV抗原。根据与人类CHIKV感染在临床和病理上的相似性，年轻的ICR和CD-1小鼠为进一步研究CHIKV感染的发病机理和治疗提供了有用且现实的模型。

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