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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on Loa loa microfilaremia.
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A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on Loa loa microfilaremia.

机译：评估奎宁，氯喹，阿莫地喹和青蒿琥酯对Loa loa微丝血症的影响的对照试验。

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摘要

Onchocerciasis control is currently based on mass ivermectin treatment. Unfortunately, this drug can induce serious adverse events (SAEs) in persons with high levels of Loa loa microfilaremia (> 30,000 microfilaria/mL). A means of preventing SAEs would be to treat at risk populations with a drug that would progressively reduce the microfilarial loads before administering ivermectin. Antimalarial drugs are a potential solution because they have shown some activity against various filarial species. A controlled trial was conducted to assess the effect of standard doses of quinine, chloroquine, amodiaquine, and artesunate on L. loa microfilaremia. Ninety-eight patients were randomly allocated into five groups (one for each drug and a control group) after stratification on microfilarial load. Loa loa microfilaremia was monitored on days 0, 3, 7, 15, 30, 60, and 90. No significant change in the loads was recorded in any of the treatment groups. A comprehensive review of the effects of antimalarial drugs against filariae is also provided.
机译：盘尾丝虫病的防治目前基于伊维菌素的大规模治疗。不幸的是，这种药物会在高水平的Loa loa微丝血症（> 30,000 microfilaria / mL）的人群中引起严重的不良事件（SAE）。预防SAE的一种方法是在服用伊维菌素之前用逐渐降低微丝负荷的药物治疗高危人群。抗疟药是一种潜在的解决方案，因为它们已显示出对各种丝虫种的活性。进行了一项对照试验，以评估标准剂量的奎宁，氯喹，阿莫地喹和青蒿琥酯对loa loa微丝血症的影响。在微丝负荷分层后，将98例患者随机分为5组（每种药物一组，对照组）。在第0、3、7、15、30、60和90天监测Loa loa微丝蛋白血症。在任何治疗组中，未记录负荷的显着变化。还提供了抗疟药对丝虫病作用的全面综述。

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