Voltage-gated sodium channel polymorphism and metabolic resistance in pyrethroid-resistant Aedes aegypti from Brazil.

Martins AJ; Lins RM; Linss JG

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Voltage-gated sodium channel polymorphism and metabolic resistance in pyrethroid-resistant Aedes aegypti from Brazil.

机译：来自巴西的拟除虫菊酯抗性埃及伊蚊的电压门控钠通道多态性和代谢抗性。

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The nature of pyrethroid resistance in Aedes aegypti Brazilian populations was investigated. Quantification of enzymes related to metabolic resistance in two distinct populations, located in the Northeast and Southeast regions, revealed increases in Glutathione-S-transferase (GST) and Esterase levels. Additionally, polymorphism was found in the IIS6 region of Ae. aegypti voltage-gated sodium channel (AaNa(V)), the pyrethroid target site. Sequences were classified in two haplotype groups, A and B, according to the size of the intron in that region. Rockefeller, a susceptible control lineage, contains only B sequences. In field populations, some A sequences present a substitution in the 1011 site (Ile/Met). When resistant and susceptible individuals were compared, the frequency of both A (with the Met mutation) and B sequences were slightly increased in resistant specimens. The involvement of the AaNa(V) polymorphism in pyrethroid resistance and the metabolic mechanisms that lead to potential cross-resistance between organophosphate and pyrethroids are discussed.

机译：研究了埃及伊蚊的拟除虫菊酯抗药性。对位于东北和东南地区的两个不同种群中与代谢抗性相关的酶进行定量，发现谷胱甘肽-S-转移酶（GST）和酯酶水平增加。此外，在Ae的IIS6区域中发现了多态性。埃及除虫菊酯电压门控钠通道（AaNa（V）），拟除虫菊酯靶位。根据该区域内含子的大小，将序列分为两个单倍型组A和B。洛克菲勒（Rockefeller）是易感的控制谱系，仅包含B序列。在田间种群中，一些A序列在1011位点（Ile / Met）出现取代。当比较抗药性和易感个体时，抗药性样品中A（具有Met突变）和B序列的频率均略有增加。讨论了AaNa（V）多态性与拟除虫菊酯抗性的关系以及导致有机磷酸酯和拟除虫菊酯之间潜在交叉耐药性的代谢机制。

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《The American Journal of Tropical Medicine and Hygiene》 |2009年第1期|共8页
作者
Martins AJ; Lins RM; Linss JG;
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1. Voltage-gated sodium channel polymorphism and metabolic resistance in pyrethroid-resistant Aedes aegypti from Brazil. [J] . Martins AJ, Lins RM, Linss JG The American Journal of Tropical Medicine and Hygiene . 2009,第1期

机译：来自巴西的拟除虫菊酯抗性埃及伊蚊的电压门控钠通道多态性和代谢抗性。
2. V1016G Point Mutation: The Key Mutation in the Voltage-Gated Sodium Channel (Vgsc) Gene of Pyrethroid-Resistant Aedes aegypti (Diptera: Culicidae) in Indonesia [J] . Amelia-Yap Zheng Hua, Sofian-Azirun Mohd, Chen Chee Dhang, Journal of Medical Entomology . 2019,第4期

机译：v1016g点突变：印度尼西亚拟除虫菊酯AEDES（Diptera：Culicidae）的电压门控钠通道（VGSC）基因的关键突变
3. Co-occurrence of Point Mutations in the Voltage-Gated Sodium Channel of Pyrethroid-Resistant Aedes aegypti Populations in Myanmar [J] . Hitoshi Kawada, Sai Zaw Min Oo, Sein Thaung, PLOS Neglected Tropical Diseases . 2014,第7期

机译：缅甸拟除虫菊酯抗性埃及伊蚊种群的电压门控钠通道中点突变的共现。
4. The diversity of kdr allele mutation, and resistance detection in the voltage-gated sodium channel of Culex pipiens pallens from Shandong Province, China [C] . Peng Cheng, Hongmei Liu, Xiaodan Huang, International Conference on Human Health and Medical Engineering. . 2014

机译：中国山东省山东省Culex pipiens Pallens电压门控钠通道的kdr等位基因突变和抗性检测的多样性
5. Molecular interactions between sodium channels and a novel neurotoxin, ProTx-II: Implications for the structure and function of voltage-gated sodium channels. [D] . Smith, Jaime J. 2007

机译：钠通道与新型神经毒素ProTx-II之间的分子相互作用：对电压门控钠通道的结构和功能的影响。
6. Co-occurrence of Point Mutations in the Voltage-Gated Sodium Channel of Pyrethroid-Resistant Aedes aegypti Populations in Myanmar [O] . Hitoshi Kawada, Sai Zaw Min Oo, Sein Thaung, 2014

机译：缅甸拟除虫菊酯抗性埃及伊蚊种群的电压门控钠通道中点突变的共现。
7. Co-occurrence of point mutations in the voltage-gated sodium channel of pyrethroid-resistant Aedes aegypti populations in Myanmar. [O] . Hitoshi Kawada, Sai Zaw Min Oo, Sein Thaung, 2014

机译：在缅甸的拟除虫菊酯抗性埃及伊蚊种群的电压门控钠通道中共点突变。

Voltage-gated sodium channel polymorphism and metabolic resistance in pyrethroid-resistant Aedes aegypti from Brazil.

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