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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice.
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Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice.

机译：蒿甲醚和甲氟喹对无胸腺和免疫能力强的NMRI小鼠的少年和成年曼氏血吸虫的活性。

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摘要

Immune effector mechanisms can enhance the activity of antischistosomal drugs. We examined the in vivo effect of single oral doses of the antimalarials artemether (400 mg/kg) and mefloquine (200 mg/kg), recently described to have promising antischistosomal properties, against juvenile and adult Schistosoma mansoni in T cell-deficient and in comparably infected age- and sex-matched immunologically intact control mice. Artemether and mefloquine are equally effective in athymic and immunocompetent mice. Artemether treatment resulted in total and female worm burden reductions ranging between 71.1% and 85.3%, whereas mefloquine achieved total and female worm burden reductions of 80.4-97.8%. In conclusion, artemether and mefloquine act T-cell independently and no synergistic interaction with the immune response was involved.
机译：免疫效应器机制可以增强抗血吸虫病药物的活性。我们检查了单次口服抗疟药蒿甲醚（400 mg / kg）和甲氟喹（200 mg / kg）的体内作用，这些药物最近被描述具有针对儿童和成人曼氏血吸虫的T型血吸虫病和贫血的抗血吸虫病特性。比较感染的年龄和性别匹配的免疫原性对照小鼠。蒿甲醚和甲氟喹在无胸腺和免疫功能正常的小鼠中同样有效。蒿甲醚处理可使总蠕虫和雌虫蠕虫的减少量在71.1％和85.3％之间，而甲氟喹的总蠕虫和雌虫蠕虫的减少量为80.4-97.8％。总之，蒿甲醚和甲氟喹独立地作用于T细胞，并且不涉及与免疫反应的协同相互作用。

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