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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.
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Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.

机译：人类对冈比亚按蚊唾液的抗体反应：一种免疫流行病学生物标记物，用于评估经杀虫剂处理的蚊帐在疟疾媒介控制中的功效。

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摘要

For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.
机译：为了与疟疾作斗争，世界卫生组织（世卫组织）强调需要指标来评估病媒控制策略的有效性。这项研究基于人类对唾液按蚊的抗体反应，研究了一种潜在的免疫学标记物，作为评估杀虫剂处理过的蚊帐（ITN）功效的新指标。在引入ITN之前和之后，对来自安哥拉疟疾流行地区的儿童和成年人进行了寄生虫学，昆虫学和免疫学评估。免疫球蛋白G（IgG）的水平达到An。冈比亚的唾液与An的强度呈正相关。冈比亚接触和疟疾感染。引入ITN后，观察到抗唾液IgG反应显着下降，这与寄生虫负荷下降有关。这项研究代表了评估疟疾媒介控制策略功效的新指标开发的第一阶段，该指标可应用于其他节肢动物媒介传播疾病。

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