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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Sentinel chicken seroconversions track tangential transmission of West Nile virus to humans in the greater Los Angeles area of California.
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Sentinel chicken seroconversions track tangential transmission of West Nile virus to humans in the greater Los Angeles area of California.

机译：前哨鸡的血清转化跟踪西尼罗河病毒向人类在加利福尼亚大洛杉矶地区的切向传播。

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摘要

In Los Angeles, California, West Nile virus (WNV) has followed a pattern of emergence, amplification, subsidence, and resurgence. A time series cross-correlation analysis of human case counts and sentinel chicken seroconversions revealed temporal concordance indicating that chicken seroconversions tracked tangential transmission of WNV from the basic passeriform-Culex amplification cycle to humans rather than antecedent enzootic amplification. Sentinel seroconversions provided the location and time of transmission as opposed to human cases, which frequently were reported late and were assumed to be acquired 2-14 days before disease onset at their residence. Cox models revealed that warming degree-days were associated with the increased risk of seroconversion, whereas elevated herd immunity in peridomestic birds dampened seroconversion risk. Spatially, surveillance data collected within a 5 km radius of flock locations 15-28 days before the bleed date were most predictive of a seroconversion. In urban Los Angeles, sentinel chicken seroconversions could be used as an outcome measure in decision support for emergency intervention.
机译：在加利福尼亚州的洛杉矶，西尼罗河病毒（WNV）遵循了出现，扩增，沉陷和死灰复燃的模式。对人类病例数和前哨鸡血清转化的时间序列互相关分析显示时间一致性，表明鸡肉血清转化追踪WNV从基本Passeriform-Culex扩增循环向人类的切向传播，而不是先前的动物放大。与人类病例相反，前哨血清转化提供了传播的位置和时间，而人类病例通常报道较晚，并假定是在其住所发病前2-14天获得的。考克斯模型表明，变暖日数与血清转化的风险增加有关，而在家禽中提高的畜群免疫力降低了血清转化的风险。在空间上，在出血日期前15-28天，在鸡群位置5公里半径内收集的监测数据最能预测血清转化。在洛杉矶市区，前哨鸡的血清转化可以用作紧急干预决策支持中的一项结果指标。

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