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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium.
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Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium.

机译：血吸虫血吸虫选择性人群化疗后，长期抑制成人膀胱发病和严重肾积水。

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摘要

Repeated selective population chemotherapy of school age children reduces infection and morbidity associated with Schistosoma haematobium infection. To examine the long-term effect of this treatment on susceptibility to re-infection and late disease, a cohort of Kenyans (n = 194) were re-examined for infection and urinary tract morbidity 7-13 years after they underwent annual ultrasonography and treatment for an average of 5 years beginning in 1984 as children. Controls were previously untreated age-matched individuals residing in the same or adjacent villages. The overall prevalence and intensity of infection were equivalent between the 2 groups. In contrast, the prevalence of bladder wall pathology was 11-fold lower in previously treated (1.5%) versus untreated subjects (17%). Severe hydronephrosis was completely reversed. These data demonstrate that treatment significantly reduced urinary tract morbidity despite re-infection, and suggest that the important risk factors for urinary tract morbidity in adulthood are cumulative intensity and duration of infection during early adolescence.
机译：反复对学龄儿童进行选择性人群化学疗法可减少血吸虫血吸虫感染相关的感染和发病率。为了检查这种治疗对再感染和晚期疾病易感性的长期影响，对一组肯尼亚人（n = 194）进行了年度超声检查和治疗后7-13年，对他们的感染和尿路发病率进行了重新检查。从1984年开始，平均年龄为5岁。对照是居住在相同或相邻村庄中的，未经治疗且与年龄匹配的个体。两组的总体感染率和感染强度相同。相比之下，先前治疗的膀胱壁病理学患病率（1.5％）比未治疗的受试者（17％）低11倍。严重肾积水完全逆转。这些数据表明，尽管再次感染，治疗仍可显着降低尿路发病率，并表明成年期尿路发病的重要危险因素是青春期早期的累积强度和感染持续时间。

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