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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Serologic diagnosis of human taenia solium cysticercosis by using recombinant and synthetic antigens in QuickELISA.
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Serologic diagnosis of human taenia solium cysticercosis by using recombinant and synthetic antigens in QuickELISA.

机译：在QuickELISA中使用重组和合成抗原对人牛带en虫囊尾rc病进行血清学诊断。

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摘要

Diagnosis of Taenia solium cysticercosis is an important component in the control and elimination of cysticercosis and taeniasis. New detection assays using recombinant and synthetic antigens originating from the lentil lectin-purified glycoproteins (LLGPs) of T. solium cysticerci were developed in a QuickELISA format. We analyzed a panel of 474 serum samples composed of 108 serum samples from donors with two or more viable cysts, 252 serum samples from persons with other parasitic infections, and 114 serum samples from persons with no documented illnesses. The sensitivities and specificities of T24H QuickELISA, GP50 QuickELISA, and Ts18var1 QuickELISA were 96.3% and 99.2%, 93.5% and 98.6%, and 89.8% and 96.4%, respectively, for detecting cases with multiple, viable cysts. T24H QuickELISA performs best among the three assays, and has sensitivity and specificity values comparable to those of the LLGP enzyme-linked immunosorbent blot. The QuickELISA are simple, rapid quantitative methods for detecting antibodies specific for T. solium cysticerci antigens.
机译：en虫囊尾病的诊断是控制和消除囊尾and病和虫病的重要组成部分。以QuickELISA格式开发了使用来源于扁豆凝集素纯化的糖衣原体的糖蛋白（LLGPs）的重组和合成抗原的新检测方法。我们分析了一组474个血清样本，其中包括来自两个或两个以上活囊肿的捐献者的108个血清样本，来自其他寄生虫感染的人的252个血清样本和没有证据的人的114个血清样本。 T24H QuickELISA，GP50 QuickELISA和Ts18var1 QuickELISA的敏感性和特异性分别为96.3％和99.2％，93.5％和98.6％，89.8％和96.4％，用于检测有多个活囊肿的病例。 T24H QuickELISA在这三种测定中表现最佳，其灵敏度和特异性值可与LLGP酶联免疫吸附印迹法相媲美。 QuickELISA是一种简单，快速的定量方法，用于检测特异于T. solium cysticerci抗原的抗体。

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