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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Reductions in artemisinin-based combination therapy consumption after the nationwide scale up of routine malaria rapid diagnostic testing in Zambia
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Reductions in artemisinin-based combination therapy consumption after the nationwide scale up of routine malaria rapid diagnostic testing in Zambia

机译：赞比亚在全国范围内扩大常规疟疾快速诊断检测后，减少基于青蒿素的联合疗法的消费

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摘要

The National Malaria Control Center of Zambia introduced rapid diagnostic tests (RDTs) to detect Plasmodium falciparum as a pilot in some districts in 2005 and 2006; scale up at a national level was achieved in 2009. Data on RDT use, drug consumption, and diagnostic results were collected in three Zambian health districts to determine the impact RDTs had on malaria case management over the period 2004-2009. Reductions were seen in malaria diagnosis and antimalarial drug prescription (66.1 treatments per facility-month (95% confidence interval [CI] = 44.7-87.4) versus 26.6 treatments per facility-month (95% CI = 11.8-41.4)) pre- and post-RDT introduction. Results varied between districts, with significant reductions in low transmission areas but none in high areas. Rapid diagnostic tests may contribute to rationalization of treatment of febrile illness and reduce antimalarial drug consumption in Africa; however, their impact may be greater in lower transmission areas. National scale data will be necessary to confirm these findings.
机译：赞比亚国家疟疾控制中心于2005年和2006年在部分地区引入了快速诊断测试（RDT），以检测恶性疟原虫。 2009年实现了在全国范围内的规模扩大。在三个赞比亚卫生区收集了有关RDT使用，药物消耗和诊断结果的数据，以确定2004-2009年期间RDT对疟疾病例管理的影响。之前和之后的疟疾诊断和抗疟药处方（每设施月66.1次治疗（95％置信区间[CI] = 44.7-87.4））与每设施月26.6次治疗（95％CI = 11.8-41.4）相比有所减少。 RDT后的介绍。各地区的结果各不相同，低传播地区明显减少，而高传播地区则没有。快速诊断测试可能有助于合理地治疗发热性疾病，并减少非洲的抗疟药物消费;但是，它们的影响在较低的传播区域可能更大。国家规模的数据对于确认这些发现将是必要的。

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