...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease
【24h】

Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease

机译：老年痴呆症中与年龄相关的黄斑变性相关基因

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: Given the clinical and pathological similarities between age-related macular degeneration (AMD) and Alzheimer disease (AD), to assess whether AMD-associated single nucleotide polymorphisms (SNPs), including those from complementrelated genes, are associated with AD. Design: A case-control association study-type design. Setting: A UK tertiary care dementia clinic. Participants: 322 cognitively normal participants and 258 cases with a clinical diagnosis of AD. Measurements: Polymorphisms in the following genes were studied: CFH, ARMS2, C2/CFB, C3, CFI/PLA2G12a, SERPING1, TLR3, TLR4, CRP, APOE, and TOMM40. Haplotypes were analysed for CFH, TOMM40, and APOE. Univariate analysis was performed for each genetic change and case-comparator status, and then correction for multiple testing performed. Results: The presence of an epsilon 4 APOE allele was significantly associated with AD. No association was evident between CFH SNPs or haplotypes, or other AMD-associated SNPs tested, and AD. The exceptions were TOMM40 SNPs, which were associated with AD even after correction for multiple comparisons. The associations disappeared, however, when entered into a regression model including APOE genotypes. Conclusions: The results for most SNPs tested, as well as CFH haplotypes, are novel. The functional effects of abnormal complement activity in AD's pathogenesis may be contradictory, but methodological reasons may underlie the lack of association-for example, genetic changes other than SNPs being involved.
机译：目的：鉴于年龄相关性黄斑变性（AMD）和阿尔茨海默病（AD）在临床和病理上的相似性，以评估AMD相关的单核苷酸多态性（SNP），包括来自补体相关基因的单核苷酸多态性是否与AD相关。设计：病例对照协会研究型设计。地点：英国三级护理痴呆症诊所。参与者：322名认知正常参与者和258例临床诊断为AD的病例。测量：研究了以下基因的多态性：CFH，ARMS2，C2 / CFB，C3，CFI / PLA2G12a，SERPING1，TLR3，TLR4，CRP，APOE和TOMM40。分析了CFH，TOMM40和APOE的单倍型。对每个遗传变化和病例比较者状态进行单变量分析，然后对多项测试进行校正。结果：ε4 APOE等位基因的存在与AD显着相关。在CFH SNP或单倍型或其他与AMD相关的SNP与AD之间没有明显的关联。 TOMM40 SNP是例外，即使经过多次比较校正，它们仍与AD相关。但是，当进入包含APOE基因型的回归模型时，关联消失了。结论：大多数测试的SNP以及CFH单倍型的结果都是新颖的。补体活性异常在AD发病机制中的功能作用可能是矛盾的，但是方法学原因可能是缺乏关联的原因-例如，涉及SNP以外的遗传改变。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号