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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Phobic anxiety and cognitive performance over 4 years among community-dwelling older women in the Nurses' Health Study
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Phobic anxiety and cognitive performance over 4 years among community-dwelling older women in the Nurses' Health Study

机译：在《护士健康研究》中，社区居住的老年妇女超过4年的恐惧焦虑和认知表现

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Objective: To examine the relation of phobic anxiety to late-life cognitive trajectory. Design: Prospective cohort. Setting: Nurses' Health Study-U.S. registered nurses. Participants: A total of 16,351 women among whom phobic anxiety symptoms were assessed in 1988 (mean age = 63 years). Measurements: Beginning a decade after phobic anxiety ascertainment (mean age = 74 years), three assessments of general cognition, word and paragraph immediate and delayed recall, category fluency, and attention or working memory were administered over an average of 4.4 years; global cognitive and verbalmemory composite scoreswere generated fromthe component tests. General linear models of response profiles were used to evaluate relations of phobic anxiety to initial cognitive performance and subsequent change. Results: Higher phobic anxiety was associated with poorer initial performance: for example, comparing women with the highest anxiety to those with no or minimal symptoms, the multivariate-adjusted mean difference (95% confidence interval) in scores was -0.10 (-0.13,-0.06) standard units for the global score summarizing all tests, and -0.08 (-0.11,-0.04) standard units for verbal memory (summarizing four word- and paragraph-recall tasks). Mean differences between extreme categories of phobic anxiety were equal to those for participants aged 1.5-2 years apart: that is, cognitively equivalent to being about 2 years older. There were no relations of phobic anxiety to subsequent cognitive change. Conclusions: Higher mid-life phobic anxiety was related to worse later-life overall cognition and verbal memory. Yet, profiles of poorer cognition with higher anxiety remained parallel over time, suggesting phobic anxiety may impose impact on cognition earlier in life, rather than ongoing impact in later-life.
机译：目的：探讨恐惧症与晚年认知轨迹的关系。设计：预期队列。地点：美国护士健康研究注册护士。参加者：总共16,351名妇女在1988年接受了恐惧性焦虑症状的评估（平均年龄= 63岁）。测量：从确定恐惧症后的十年开始（平均年龄= 74岁），平均在4.4年内对一般认知，单词和段落的立即和延迟回忆，类别流利性以及注意力或工作记忆进行了三项评估;成分测试产生了全球认知和言语记忆综合得分。响应曲线的一般线性模型用于评估恐惧性焦虑与初始认知能力和随后变化的关系。结果：恐惧恐惧症的高发与较差的初期表现有关：例如，将焦虑程度最高的女性与无症状或症状轻微的女性进行比较，得分的多元调整后平均差异（95％置信区间）为-0.10（-0.13， -0.06）用于汇总所有测试的全局分数的标准单位，以及-0.08（-0.11，-0.04）用于言语记忆的标准单位（总结四个单词和段落调用任务）。极端类别的恐惧症之间的平均差异与相隔1.5-2岁的参与者的平均差异相等：也就是说，在认知上等同于大约2岁。恐惧感与随后的认知变化没有关系。结论：中年恐惧症的高发与较差的后期总体认知和言语记忆有关。然而，随着时间的流逝，认知水平较低，焦虑程度较高的情况仍然保持平行，这表明恐惧性焦虑可能会对生活早期的认知产生影响，而不是对以后的生活产生持续影响。

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