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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Relationship Between Cerebrovascular Risk, Cognition, and Treatment Outcome in Late-Life Psychotic Depression
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Relationship Between Cerebrovascular Risk, Cognition, and Treatment Outcome in Late-Life Psychotic Depression

机译：晚期精神病性抑郁症的脑血管风险，认知与治疗结果之间的关系

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Objective: To examine whether cerebrovascular risk, executive function, and processing speed are associated with acute treatment outcome of psychotic depression in older adults. Methods: The authors analyzed data from 142 persons aged 60 years or older with major depression with psychotic features who participated in a 12-week randomized controlled trial (RCT) comparing olanzapine plus sertraline with olanzapine plus placebo. The independent variables were baseline cerebrovascular risk (Framingham Stroke Risk Score), baseline executive function (Stroop interference score and the initiation/perseveration subscale of the Mattis Dementia Rating Scale), and baseline processing speed (color and word reading components of the Stroop). The outcome variable was change in severity of depression, measured by the 17-item Hamilton Depression Rating Scale total score, during the course of the RCT. Results: Greater baseline cerebrovascular risk was significantly associated with less improvement in depression severity over time, after controlling for pertinent covariates. Neither executive function nor processing speed predicted outcome. Conclusion: This study suggests an association of cerebrovascular risk, but not executive function or processing speed, with treatment outcome of major depression with psychotic features in older adults.
机译：目的：探讨老年人的脑血管风险，执行功能和处理速度是否与精神病性抑郁症的急性治疗结果相关。方法：作者分析了来自142名年龄在60岁以上，具有精神病特征的重度抑郁症患者的数据，他们参加了为期12周的随机对照试验（RCT），比较了奥氮平加舍曲林与奥氮平加安慰剂的比较。独立变量是基线脑血管风险（Framingham中风风险评分），基线执行功能（Stroop干扰评分和Mattis痴呆症评分量表的开始/持续性次级量表）和基线处理速度（Stroop的颜色和单词阅读成分）。结果变量是在RCT过程中抑郁症严重程度的变化，该变化由17个项的汉密尔顿抑郁量表评分得出。结果：控制相关协变量后，基线脑血管风险升高与抑郁症严重程度随时间的改善减少显着相关。执行功能和处理速度均不能预测结果。结论：这项研究表明，老年人的脑血管风险与主要抑郁症伴有精神病特征的治疗结果有关，但与执行功能或处理速度无关。

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