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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults
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Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults

机译：认知正常的成年人中的主观认知投诉，个性和脑淀粉样蛋白

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Objective: Subjective cognitive complaints in otherwise normal aging are common but may be associated with preclinical Alzheimer disease in some individuals. Little is known about who is mostly likely to show associations between cognitive complaints and preclinical Alzheimer pathology. We sought to demonstrate associations between subjective complaints and brain amyloid-beta in cognitively normal older adults; and to explore personality factors as potential moderators of this association. Design: Cross-sectional observational study. Setting: Clinical neuroimaging research center. Participants: Community volunteer sample of 92 healthy older adults, screened for normal cognition with comprehensive neuropsychological evaluation. Measurements: Subjective cognitive self-report measures included the Memory Functioning Questionnaire (MFQ), Cognitive Failures Questionnaire, and the Subjective Cognitive Complaint Scale. Personality was measured with the NEO Five Factor Inventory. Brain amyloid-beta deposition was assessed with Pittsburgh compound B (PiB)-PET imaging. Results: One of three cognitive complaint measures, the MFQ, was associated with global PiB retention (standardized beta - -0.230, p - 0.046, adjusting for age, sex and depressive symptoms). Neuroticism moderated this association such that only high neuroticism individuals showed the predicted pattern of high complainte-high amyloid-beta association. Conclusion: Evidence for association between subjective cognition and brain amyloid-beta deposition in healthy older adults is demonstrable but measure-specific. Neuroticism may moderate the MFQ-amyloid-beta association such that it is observed in the context of higher trait neuroticism. Subjective cognitive complaints and neuroticism may reflect a common susceptibility toward psychological distress and negative affect, which are in turn risk factors for cognitive decline in aging and incident Alzheimer disease.
机译：目的：在其他情况下正常衰老中的主观认知障碍很常见，但在某些个体中可能与临床前阿尔茨海默氏病有关。关于谁最有可能表现出认知障碍和临床前阿尔茨海默氏病之间的关联知之甚少。我们试图证明认知正常老年人的主观主诉与脑淀粉样蛋白之间的关联。并探讨人格因素作为该协会的潜在主持人。设计：横断面观察研究。地点：临床神经影像研究中心。参与者：92名健康老年人的社区志愿者样本，通过全面的神经心理学评估筛选正常认知能力。测量：主观认知自我报告测量包括记忆功能问卷（MFQ），认知障碍问卷和主观认知投诉量表。人格通过NEO五因素清单进行衡量。用匹兹堡化合物B（PiB）-PET成像评估脑淀粉样蛋白β沉积。结果：三种认知投诉指标中的一种，即MFQ，与总体PiB保留相关（标准化的beta--0.230，p-0.046，针对年龄，性别和抑郁症状进行了调整）。神经质减轻了这种联系，因此只有高度神经质的人才能表现出高抱怨者-高淀粉样蛋白-β关联的预测模式。结论：在健康的成年人中，主观认知与脑淀粉样蛋白沉积之间存在关联的证据是可证实的，但具有针对性。神经质可以减轻MFQ-淀粉样蛋白-β的关联，从而在较高性格神经质的背景下观察到它。主观的认知抱怨和神经质可能反映出对心理困扰和负面影响的普遍敏感性，而这又是导致衰老和阿尔茨海默氏病认知下降的危险因素。

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