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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Elderly Benzodiazepine Users at Increased Risk of Activity Limitations: Influence of Chronicity, Indications, and Duration of Action-The Three-City Cohort
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Elderly Benzodiazepine Users at Increased Risk of Activity Limitations: Influence of Chronicity, Indications, and Duration of Action-The Three-City Cohort

机译：活动限制的风险增加的苯二氮卓老人使用者：慢性病，适应症和行动时间的影响-三城市队列

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Objective: To examine the cross-sectional and longitudinal associations between benzodiazepine use and daily activity limitations, according to drug indications and duration of action. Design: Prospective cohort study. Setting: Population-based three-city study. Participants: 6,600 participants aged 65 years and over included between 1999 and 2001 and followed after 2, 4, and 7 years. Measurements: Benzodiazepine users were separated into hypnotic, short-acting anxiolytic, and long-acting anxiolytic users and compared with non users. Three outcomes were examined assessing restrictions in mobility, instrumental activities of daily living (IADLs) and social participation. Results: In multivariate simple or mixed logistic models adjusted for sociodemographic variables, impairments and comorbidity, and for anxiety, insomnia, and depression, hypnotic benzodiazepines were moderately associated with mobility limitation prevalence and IADL limitation incidence. Short-acting and long-acting anxiolytics were associated with IADL limitation prevalence and with mobility limitation prevalence and incidence and long-acting anxiolytics were also associated with IADL limitation incidence. Chronic benzodiazepines users were at a marked risk of developing restrictions for the three outcomes; odds ratio: 1.71 (95% CI: 1.23-2.39) for mobility, 1.54 (95% CI: 1.14-2.10) for IADL, and 1.74 (95% CI: 1.23-2.47) for participation limitations. Conclusions: Benzodiazepine users are at increased risk of activity limitations regardless of the duration of action or indication. Chronic use of benzodiazepines should be avoided in order to extend disability-free survival.
机译：目的：根据药物适应症和作用时间，检查苯二氮卓类药物使用与每日活动限制之间的横向和纵向联系。设计：前瞻性队列研究。地点：基于人口的三城市研究。参与者：1999年至2001年之间，年龄在65岁以上的6,600名参与者，之后分别是2、4和7岁。评估：将苯二氮卓类药物使用者分为催眠药，短效抗焦虑药和长效抗焦虑药，并与非使用者进行比较。检查了三个结果，以评估行动不便，日常生活的工具性活动（IADL）和社会参与的限制。结果：在针对社会人口统计学变量，损伤和合并症以及焦虑症，失眠症和抑郁症进行了调整的多元简单或混合逻辑模型中，催眠性苯二氮卓类药物与活动受限和IADL限制的发生率呈中度关联。速效和长效抗焦虑药与IADL限度患病率相关，与流动性限度患病率和发病率相关，而长效抗焦虑药也与IADL限度发病率相关。长期服用苯二氮卓类药物的人有明显的风险发展这三个结局的限制。优势比：流动性为1.71（95％CI：1.23-2.39），IADL为1.54（95％CI：1.14-2.10），参与限制为1.74（95％CI：1.23-2.47）。结论：苯二氮卓类药物使用者活动受限的风险增加，无论作用持续时间或适应症如何。应当避免长期使用苯二氮卓类药物，以延长无残疾生存期。

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