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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders: A Preliminary Study
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Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders: A Preliminary Study

机译：主动语义干扰与非骨水泥社区居民中老年人的总淀粉样蛋白和区域淀粉样蛋白异常有关：初步研究

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Objective: To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders. Methods: 27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging. Results: High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed. Conclusions: In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.
机译：目的：探讨非痴呆老年人对主动语义干扰（PSI）和追溯语义干扰（RSI）的敏感性与脑淀粉样蛋白负荷之间的关系。方法：27名参与者（11名主观记忆障碍的认知正常[CN]，8名无记忆障碍的CN和8名轻度认知障碍[MCI]）接受了全面的神经和神经心理学评估。参与者还接受了语义干扰测试（SIT）和AV-45淀粉样蛋白PET成像。结果：总淀粉样蛋白负荷，区域淀粉样蛋白水平和PSI度量（在整个样本和不包括MCI受试者的子样本中）之间存在高度关联。 RSI和其他记忆指标显示与总淀粉样蛋白负荷和区域淀粉样蛋白负荷无明显关联。没有观察到淀粉样蛋白水平和非记忆性能之间的关联。结论：在非痴呆症患者中，对PSI的脆弱性与总的和区域性的β-淀粉样蛋白负荷高度相关，并且可能是脑病理学的早期认知指标。

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