• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >White Matter Integrity and Depressive Symptoms in Cerebral Small Vessel Disease: The RUN DMC Study
【24h】

White Matter Integrity and Depressive Symptoms in Cerebral Small Vessel Disease: The RUN DMC Study

机译：脑小血管疾病的白质完整性和抑郁症状：RUN DMC研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Depressive symptoms are common in elderly with cerebral small vessel disease (SVD). As not every individual with SVD experiences depressive symptoms, other factors might play a role. We therefore investigated the white matter (WM) integrity of the white matter tracts in elderly with depressive symptoms, independent of global cognitive function, by applying the tract-based spatial statistics (TBSS). Design: Prospective cohort study with cross-sectional baseline data. Setting: Radboud University Nijmegen Medical Centre, The Netherlands. Participants: 438 individuals aged between 50-85 years, with SVD without dementia. Measurements: Diffusion tensor imaging parameters and depressive symptoms, assessed with the Center for Epidemiologic Studies Depression Scale. Results: Compared with non-depressed participants (N = 287), those with depressive symptoms (N = 151) had lower fractional anisotropy in the genu and body of the corpus callosum, bilateral inferior fronto-occipital fasciculus, uncinate fasciculus, and corona radiata. These differences disappeared after adjustment for white matter hyperintensities (WMH) and lacunar infarcts. Mean-, axial-and radial diffusivity were higher in these areas in participants with depressive symptoms. After additional adjustment for WMH and lacunar infarcts, the changes observed in radial diffusivity also disappeared. Adding global cognition as confounding variable altered the diffusion parameters only slightly. Conclusion: This study indicates that elderlywith depressive symptoms show a lower WM integrity, independent of global cognitive function, and that the presence of SVD is mostly responsible, affecting the fronto-subcortical regions and hereby disrupting the neural circuitry involved in mood regulation.
机译：目的：抑郁症状在脑小血管疾病（SVD）的老年人中很常见。由于并非每个患有SVD的人都会出现抑郁症状，因此其他因素也可能起作用。因此，我们通过应用基于道的空间统计数据（TBSS），调查了具有抑郁症状的老年人的白质道（WM）完整性，而与整体认知功能无关。设计：前瞻性队列研究，包括横断面基线数据。地点：荷兰拉德布德大学奈梅亨医学中心。参与者：438名年龄在50-85岁之间的人，患有SVD，无痴呆。测量：扩散张量成像参数和抑郁症状，用流行病学研究中心抑郁量表评估。结果：与未抑郁的参与者（N = 287）相比，具有抑郁症状（N = 151）的参与者在call体，双侧额枕下筋膜，未结状筋膜和电晕放射线的体和体中的分数各向异性较低。 。在调整了白质高信号（WMH）和腔隙性梗塞后，这些差异消失了。在患有抑郁症状的参与者中，这些区域的平均，轴向和径向扩散率较高。在对WMH和腔隙性梗塞进行进一步调整后，观察到的径向扩散率变化也消失了。添加全局认知作为混淆变量只会稍微改变扩散参数。结论：这项研究表明，具有抑郁症状的老年人表现出较低的WM完整性，独立于整体认知功能，并且SVD的存在是最主要的原因，影响额皮质下区域，从而破坏了涉及情绪调节的神经回路。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号