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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL)
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Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL)

机译：干预发展研究的设计与实现：在避免后期抑郁的同时保持认知（ReCALL）

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Objective: To discuss the design, rationale, and implementation of an intervention development study addressing indicated and selective prevention of depression and anxiety in individuals 60 years and older with mild cognitive impairment (MCI) and in their caregivers. Methods: In Phase I, now completed, we developed and standardized problem-solving therapy (PST) and the combined PST + moderate-intensity physical exercise (PE) intervention to be administered to participants with MCI and their caregivers together, dyadically, with both participants working with the same interventionist in the same therapy sessions. In Phase II we have been testing the interventions against enhanced usual care (EUC) and have addressed challenges to recruitment. Randomization was to one of three cells: PST + PE, PST, or EUC. Results: Although we set out to intervene dyadically, many individuals with MCI lived alone or did not have a support person who could participate in the study with them. Consequently, we modified the study to include MCI participants with and without support persons. Ninety-four participants were enrolled: 20 with MCI together with their support persons (N = 20 dyads) and 54 MCI participants without accompanying support persons. Most participants have been satisfied with the usefulness of the interventions in managing stress and cognitive problems. Conclusion: PST and moderate-intensity PE are acceptable interventions for depression and anxiety prevention in older adults with MCI and their available caregivers.
机译：目的：探讨一项针对60岁及以上轻度认知障碍（MCI）患者及其护理人员的抑郁症和焦虑症的适应症和选择性预防的干预发展研究的设计，原理和实施。方法：在现已完成的第一阶段中，我们开发并标准化了解决问题的治疗（PST）以及PST +中强度体育锻炼（PE）的联合干预措施，这些措施将对患有MCI的参与者及其照顾者进行双重管理与同一干预者在同一疗程中工作的参与者。在第二阶段，我们一直在测试针对常规护理（EUC）的干预措施，并解决了招募方面的挑战。随机分配到以下三个细胞之一：PST + PE，PST或EUC。结果：尽管我们开始进行干预，但许多MCI患者单独生活或没有支持者可以与他们一起参加研究。因此，我们对研究进行了修改，以包括有或没有支持人员的MCI参与者。共有94名参与者参加：20名MCI及其支持者（N = 20个二元组）和54名MCI参与者（没有陪同者）。大多数参与者对干预措施在管理压力和认知问题方面的实用性感到满意。结论：PST和中等强度PE是可接受的干预措施，可用于MCI老年人及其现有护理人员的抑郁症和焦虑症预防。

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