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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies
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Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies

机译：阿尔茨海默氏病和严重抑郁症之间的共享生物学途径：MicroRNA表达研究的系统评价。

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Objective: The clinical-epidemiological relationship between major depressive disorder (MDD) and Alzheimer disease (AD) suggests that they may share common neurobiologic abnormalities. Methods: The authors conducted a systematic review and identified microRNAs abnormally expressed in both AD and MDD. The pattern of microRNA regulation in each disorder and the genes regulated by each microRNA and the biologic processes and pathways regulated by these genes were identified. Results: Seventy-four microRNAs were abnormally expressed in AD and 30 in MDD; 7 were common for both disorders (hsa-let-7f-5p, hsa-miR-664a-3p, hsa-miR-361-5p, hsa-let-7g-5p, hsa-let-7d-5p, hsa-miR-191-5p, hsa-miR-26b-5p). These microRNAs interact with 45 validated genes, and the main biologic pathways and processes regulated by them were proteostasis control, maintenance of genomic integrity, regulation of transcriptional activity, immune-inflammatory control, and neurotrophic support. Conclusion: The current results suggest that the maintenance of genomic integrity, proteostasis control, immune-inflammatory regulation, and neurotrophic support are key neurobiologic links between these conditions. A comprehensive hypothetical model for the interaction between MDD, aging, and the development of AD is provided.
机译：目的：重度抑郁症（MDD）和阿尔茨海默病（AD）之间的临床流行病学关系表明，它们可能具有共同的神经生物学异常。方法：作者进行了系统的综述，并鉴定了在AD和MDD中异常表达的microRNA。确定了每种疾病中microRNA调控的模式以及每种microRNA调控的基因以及这些基因调控的生物学过程和途径。结果：AD中有74个microRNA异常表达，MDD中有30个异常表达。两种疾病常见7种（hsa-let-7f-5p，hsa-miR-664a-3p，hsa-miR-361-5p，hsa-let-7g-5p，hsa-let-7d-5p，hsa-miR -191-5p，hsa-miR-26b-5p）。这些microRNA与45个经过验证的基因相互作用，它们调控的主要生物学途径和过程是蛋白质稳态控制，基因组完整性的维持，转录活性的调控，免疫炎症控制和神经营养支持。结论：目前的结果表明，基因组完整性的维持，蛋白稳态控制，免疫炎症调节和神经营养支持是这些条件之间的关键神经生物学联系。提供了MDD，衰老和AD发展之间相互作用的综合假设模型。

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