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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Cognitive impairment in euthymic older adults with bipolar disorder: A controlled study using cognitive screening tests
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Cognitive impairment in euthymic older adults with bipolar disorder: A controlled study using cognitive screening tests

机译：正常人双相情感障碍的认知障碍：使用认知筛查测试的对照研究

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Background/Objective: Cognitive impairment is a common feature of bipolar disorder (BD), with increased risk of developing dementia in late life. The aim of this study was to investigate the performance on cognitive screening tests in a sample of older adults with BD, as compared to non-BD subjects. Methods: 186 older adults (86 with BD and 100 without BD) were included. Patients were stratified according to cognitive performance (normal cognition, mild impairment, and dementia). The comparison group comprised healthy controls; subjects with cognitive impairment but no dementia (CIND); or patients with probable or possible Alzheimer disease (AD). Sixty-five subjects were cognitively unimpaired (35 BD), 65 had CIND (25 BD), and 56 AD (26 BD). In each of these levels of cognitive function, we compared the performance of BD and non-BD subjects on the Mini-Mental State Examination (MMSE), verbal fluency test (VFT), and the Clock Drawing Test (CDT). Results: Nondemented patients with BD had a slightly worse global cognitive performance as compared with healthy controls and patients with CIND, as shown by lower scores on the MMSE. Similarly, BD patients performed worse on the VFT, both in the normal cognition range and in the dementia range. Finally, demented BD patients had a significantly worse performance on the CDT as compared with patients with dementia due to AD. Conclusion: Older adults with BD perform significantly worse on some cognitive screening tests as compared with those without BD across different levels of cognition.
机译：背景/目的：认知障碍是双相情感障碍（BD）的常见特征，在后期生活中患痴呆症的风险增加。这项研究的目的是调查与非BD受试者相比，在患有BD的老年人样本中进行认知筛查测试的表现。方法：纳入186名老年人（86名BD患者和100名BD患者）。根据认知能力（正常认知，轻度障碍和痴呆）对患者进行分层。对照组为健康对照组。有认知障碍但无痴呆的受试者（CIND）;或患有或可能患有阿尔茨海默病（AD）的患者。六十五名受试者的认知能力未受损（35 BD），65名CIND（25 BD）和56 AD（26 BD）。在这些认知功能的每个级别中，我们比较了BD和非BD受试者在小心理状态考试（MMSE），语言流利度测试（VFT）和时钟绘图测试（CDT）上的表现。结果：MMSE评分较低表明，与健康对照组和CIND患者相比，BD的非痴呆患者的整体认知能力稍差。同样，BD患者在正常认知范围和痴呆范围内的VFT表现均较差。最后，与AD引起的痴呆患者相比，痴呆的BD患者在CDT上的表现明显较差。结论：在不同的认知水平上，患有BD的老年人在某些认知筛查测试中的表现要明显优于没有BD的成年人。

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