Changes in endocrine therapy: anastrozole and advanced breast cancer in postmenopausal women.

Nabholtz JM

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Changes in endocrine therapy: anastrozole and advanced breast cancer in postmenopausal women.

机译：内分泌治疗的变化：绝经后妇女的阿那曲唑和晚期乳腺癌。

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Emerging data on endocrine therapies necessitates a re-evaluation of treatment strategies for advanced breast cancer. In this review, we present data from recent studies of the third-generation, nonsteroidal aromatase inhibitor (AI) anastrozole that illustrate its changing role in the treatment of postmenopausual women with advanced breast cancer. These studies demonstrate that anastrozole is now a treatment of choice as first-line therapy for patients presenting with advanced breast cancer and for patients who have progressed to advanced disease after adjuvant therapy with tamoxifen. A further trial has also shown that anastrozole is an effective and well-tolerated alternative to tamoxifen as adjuvant treatment for postmenopausal women with early breast cancer.

机译：内分泌疗法的新数据需要对晚期乳腺癌的治疗策略进行重新评估。在这篇综述中，我们提供了来自第三代非甾体芳香化酶抑制剂（AI）阿那曲唑的最新研究数据，这些数据说明了其在绝经后女性晚期乳腺癌治疗中的作用变化。这些研究表明，对于患有晚期乳腺癌的患者以及在他莫昔芬辅助治疗后已发展为晚期疾病的患者，阿那曲唑现在是首选治疗方法。进一步的试验还表明，阿那曲唑是代替他莫昔芬的有效且耐受良好的替代品，用于绝经后早期乳腺癌的辅助治疗。

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《The American journal of hospice and palliative care》 |2004年第6期|共9页
作者
Nabholtz JM;
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正文语种 eng
中图分类临床医学;
关键词
Malignant neoplasm of breast; anastrozole; Human Females; therapeutic aspects;

机译：乳腺恶性肿瘤;阿那曲唑;女性;治疗方面;

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1. Changes in endocrine therapy: anastrozole and advanced breast cancer in postmenopausal women. [J] . Nabholtz JM The American journal of hospice and palliative care . 2004,第6期

机译：内分泌治疗的变化：绝经后妇女的阿那曲唑和晚期乳腺癌。
2. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. [J] . Osborne CK reastcenter.tmc.edu, Pippen J, Jones SE, Journal of Clinical Oncology . 2002,第16期

机译：一项双盲，随机试验，比较了氟维司群和阿那曲唑对绝经后女性在接受内分泌治疗之前进展为晚期乳腺癌的疗效和耐受性：一项北美试验的结果。
3. Health-related quality of life, psychological distress, and adverse events in postmenopausal women with breast cancer who receive tamoxifen, exemestane, or anastrozole as adjuvant endocrine therapy: National Surgical Adjuvant Study of Breast Cancer 04 (N-SAS BC 04) [J] . Hiroyuki Takei, Shozo Ohsumi, Kojiro Shimozuma, Breast Cancer Research and Treatment . 2012,第1期

机译：接受三苯氧胺，依西美坦或阿那曲唑作为辅助内分泌治疗的绝经后乳腺癌女性的健康相关生活质量，心理困扰和不良事件：《美国国家乳腺癌外科手术辅助研究》 04（N-SAS BC 04）
4. A social cognitive theory-based framework for monitoring medication adherence applied to endocrine therapy in breast cancer survivors [C] . Mehdi Boukhechba, Sonia Baee, Alicia L. Nobles, IEEE EMBS International Conference on Biomedical and Health Informatics . 2018

机译：基于社会认知理论的监测药物依从性的框架应用于乳腺癌幸存者的内分泌治疗
5. A time to question: A study of the information needs of postmenopausal breast cancer patients regarding endocrine therapy. [D] . TeBrake, Melissa Lynn. 2010

机译：问题时间：对绝经后乳腺癌患者有关内分泌治疗的信息需求的研究。
6. Clinical and endocrine data for goserelin plus anastrozole as second-line endocrine therapy for premenopausal advanced breast cancer [O] . D P Forward, K L Cheung, L Jackson, 2004

机译：戈舍瑞林加阿那曲唑作为绝经前晚期乳腺癌二线内分泌治疗的临床和内分泌数据
7. Clinical and endocrine data for goserelin plus anastrozole as second-line endocrine therapy for premenopausal advanced breast cancer [O] . Forward, D P, Cheung, K L, Jackson, L, 2004

机译：戈舍瑞林加阿那曲唑作为绝经前晚期乳腺癌二线内分泌治疗的临床和内分泌数据
8. Systematic Reviews of Randomized Controlled Trials of Chemotherapy and Endocrine Therapy in Advanced Breast Cancer [R] . Simes, J. 2000

机译：系统评价晚期乳腺癌化疗和内分泌治疗的随机对照试验

Changes in endocrine therapy: anastrozole and advanced breast cancer in postmenopausal women.

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