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Management of constipation in palliative care patients undergoing opioid therapy: is polyethylene glycol an option?

机译:接受阿片类药物治疗的姑息治疗患者的便秘管理:聚乙二醇是一种选择吗?

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This study assessed the efficacy of laxative use for treatment of constipation in patients receiving opioid therapy, with special attention to polyethylene glycol 3350/electrolyte solution (PEG-ES). Computerized data from 206 patients were analyzed using descriptive statistics. Subgroups were analyzed using confirmatory statistics. Constipation occurred in 42.7 percent of patients. Laxatives were administered to 74.3 percent of these patients using a standardized step scheme, with good results in 78.4 percent. As a therapy for constipation, the combined administration of PEG-ES, sodium picosulphate, and liquid paraffin proved most effective, although statistical analysis yielded no significance. Early use of PEG-ES using a step scheme holds promise for treatment of opioid-related constipation in palliative care patients, although further investigation is warranted.
机译:这项研究评估了在接受阿片类药物治疗的患者中使用泻药治疗便秘的疗效,并特别注意了聚乙二醇3350 /电解质溶液(PEG-ES)。使用描述性统计数据分析了来自206位患者的计算机数据。使用验证性统计分析亚组。便秘发生在42.7%的患者中。使用标准化步骤方案向这些患者中的74.3%服用泻药,有78.4%的良好结果。作为一种便秘疗法,尽管统计分析没有意义,但PEG-ES,皮硫酸钠和液体石蜡的联合给药被证明是最有效的。尽管有必要做进一步的研究,但采用逐步治疗方案早期使用PEG-ES有望为姑息治疗患者的阿片类相关性便秘提供治疗。

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