Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics.

Mystakidou K; Katsouda E; Parpa E; Tsiatas ML; Vlahos L

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Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics.

机译：口服粘膜柠檬酸芬太尼用于治疗癌症患者的突破性疼痛：其药理和临床特征概述。

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Breakthrough pain is a transitory flare of pain occurring in most cancer patients against a background of otherwise controlled persistent pain. Treatment of breakthrough pain is a challenging phenomenon. Oral transmucosal fentanyl citrate (Actiq, Cephalon, Inc, West Chester, PA), a new opioid formulation with a unique delivery system, reflects the characteristics of breakthrough pain (rapid onset of action and short duration), making it an effective treatment for cancer patients who already receive opioids and experience flares of pain. This review article aims to present the role of oral transmucosal fentanyl citrate in the management of breakthrough pain in cancer patients. In particular, it is going to discuss the synthesis, clinical pharmacology, pharmacokinetic and pharmacodynamic properties, toxicity, and clinical efficacy of this novel agent.

机译：突破性疼痛是在大多数癌症患者中发生的短暂疼痛发作，其背景是本来可以控制的持续性疼痛。突破性疼痛的治疗是具有挑战性的现象。口服透粘膜柠檬酸芬太尼（Actiq，Cephalon，Inc，West Chester，PA）是一种新型阿片制剂，具有独特的给药系统，反映了突破性疼痛的特征（起效快且持续时间短），使其成为有效的癌症治疗方法已经接受阿片类药物并经历过耀斑的患者。这篇综述文章旨在介绍口服透粘膜柠檬酸芬太尼在治疗癌症患者突破性疼痛中的作用。特别是，将讨论这种新型药物的合成，临床药理学，药代动力学和药效学性质，毒性和临床功效。

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《The American journal of hospice and palliative care》 |2005年第3期|共5页
作者
Mystakidou K; Katsouda E; Parpa E; Tsiatas ML; Vlahos L;
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正文语种 eng
中图分类临床医学;
关键词
Pain; Malignant Neoplasms; Fentanyl Citrate; Oral; pharmacological; 疼痛;

机译：疼痛;恶性肿瘤;柠檬酸芬太尼;口服;药理学;疼痛;

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1. 芬太尼透皮贴剂治疗造血干细胞移植相关性口腔粘膜炎所致严重疼痛 [J] . 黄慧强, 蔡清清, 林旭滨, 癌症（英文版） . 2007,第004期
2. Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics. [J] . Mystakidou K, Katsouda E, Parpa E, The American journal of hospice and palliative care . 2005,第3期

机译：口服粘膜柠檬酸芬太尼用于治疗癌症患者的突破性疼痛：其药理和临床特征概述。
3. Oral transmucosal fentanyl citrate: overview of pharmacological and clinical characteristics. [J] . Mystakidou K, Katsouda E, Parpa E, Drug delivery. . 2006,第4期

机译：口服透粘膜枸tan酸芬太尼：药理和临床特征概述。
4. Oral transmucosal fentanyl citrate (OTFC) for the treatment of breakthrough pain in cancer patients: a controlled dose titration study. [J] . Portenoy RK, Payne R, Coluzzi P, Pain. . 1999,第2a3期

机译：口服粘膜枸tan酸芬太尼（OTFC）用于治疗癌症患者的突破性疼痛：受控剂量滴定研究。
5. Pain is a prognostic factor in association with cancer growth pattern and clinical stage in patients with oral squamous cell carcinoma [C] . Sato J, Yamazaki Y, Satoh A, European Association of Cranio-Maxillo-Facial Surgery . 2010

机译：疼痛是与口腔鳞状细胞癌患者癌症生长模式和临床阶段相关的预后因素
6. Modeling cancer pain: Elucidation of unique mechanisms and pharmacological characteristics. [D] . Wacnik, Paul William. 2003

机译：癌症疼痛建模：阐明独特的机制和药理特性。
7. Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study [O] . Arturo Cuomo, Marco Cascella, Cira Antonietta Forte, 2020

机译：通过快速发作的粘膜芬太尼谨慎地突破性癌痛治疗可改善癌症患者的生活质量：最佳多中心研究的结果
8. Oral Transmucosal Fentanyl Citrate: Randomized, Double-Blinded, Placebo-Controlled Trial for Treatment of Breakthrough Pain in Cancer Patients [O] . John T. Farrar, James Cleary, Richard Rauck, 1998

机译：口服渗滤液柠檬酸盐：随机，双盲，安慰剂对照试验，用于治疗癌症患者的突破性疼痛

Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics.

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