Acyclic Analolgues of Glucosamidine, 1-Deoxynojirimycin and N-(1,3-Dihydroxyprop-2-yl)Derivative of Valiolamine as Potential Glucosidase Inhibitors

Ashry El Sayed H.El

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Acyclic Analolgues of Glucosamidine, 1-Deoxynojirimycin and N-(1,3-Dihydroxyprop-2-yl)Derivative of Valiolamine as Potential Glucosidase Inhibitors

机译：葡糖胺，1-脱氧野rim霉素和缬氨酰胺的N-（1,3-二羟基丙-2-基）衍生物作为潜在的葡糖苷酶抑制剂的无环式类似物

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The N-(#beta#-hydroxyethyl)acetamidine (4) was prepared. Mesylation of 8 gave the 1,3-di-O-benzyl-2-O-methanesulfonyl-glycerol (9). Nucleophilic displacement of the mesyloxy group in 9 with ethanolamine and morpholine gave 11 and 12, respectively. Their catalytic hydrogenation gave 2-deoxy-2-(1-hydroxyeth-2-yl)amino-glycerol (5) and 2-deoxy-2-(morpholin-4-yl)glycerol(13). The inhibiton f the#beta#-D-glucosidase enzyme from sweet almond by 4,5and 13-16 has been studied.

机译：制备了N-（＃β＃-羟乙基）乙am（4）。 8的甲磺酰化得到1,3-二-O-苄基-2-O-甲磺酰基甘油（9）。用乙醇胺和吗啉对9中的甲磺酰氧基进行亲核取代，分别得到11和12。他们的催化加氢得到2-脱氧-2-（1-羟基乙-2-基）氨基甘油（5）和2-脱氧-2-（吗啉-4-基）甘油（13）。研究了4,5和13-16对甜杏仁中β-D-D-葡萄糖苷酶的抑制作用。

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《Tetrahedron》 |1999年第8期|共8页
作者
Ashry El Sayed H.El;
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正文语种 eng
中图分类有机化学;
关键词
Acetamidine; Glycerol; Hydroxyethylamino; Morpholine; Glucosidase inhibitors;

机译：乙酰胺;甘油;羟乙氨基;吗啉;葡萄糖苷酶抑制剂;

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1. Acyclic Analolgues of Glucosamidine, 1-Deoxynojirimycin and N-(1,3-Dihydroxyprop-2-yl)Derivative of Valiolamine as Potential Glucosidase Inhibitors [J] . Ashry El Sayed H.El Tetrahedron . 1999,第8期

机译：葡糖胺，1-脱氧野rim霉素和缬氨酰胺的N-（1,3-二羟基丙-2-基）衍生物作为潜在的葡糖苷酶抑制剂的无环式类似物
2. A New Class of Glucosidase Inhibitor:Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol with Different Ring Heteroatom Substituents and Acyclic Chain Extension [J] . Hui Liu, Lyann Sim, David R.Rose, The Journal of Organic Chemistry . 2006,第8期

机译：一类新型的葡糖苷酶抑制剂：具有不同环杂原子取代基和无环扩链的天然存在的葡糖苷酶抑制剂Salacinol的类似物
3. A New Class of Glucosidase Inhibitor:Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol with Different Ring Heteroatom Substituents and Acyclic Chain Extension [J] . Hui Liu, Lyann Sim, David R.Rose, The Journal of Organic Chemistry . 2006,第8期

机译：一类新型的葡糖苷酶抑制剂：具有不同环杂原子取代基和无环扩链的天然存在的葡糖苷酶抑制剂Salacinol的类似物
4. sp~2-IMINOSUGAR N-, S- AND C-GLYCOSIDES AS SELECTIVE INHIBITORS OF NEUTRAL α-GLUCOSIDASES: EFFECT IN THE PROGRESSION OF HUMAN BREAST CANCER CELLS [C] . Risquez-Cuadro R., Sanchez-Fernandez E. M., Allan G. International Carbohydrate Symposium . 2013

机译：Sp〜2- ininoolugar n-，s-和c-糖苷作为中性α-葡糖苷酶的选择性抑制剂：在人乳腺癌细胞的进展中的作用
5. Synthesis of novel topoisomerase-I inhibiting naphtholo-xanthone derivatives as potential anti-cancer agents. [D] . Silber, Lisa Michelle. 2013

机译：合成新型拓扑异构酶-I抑制萘并蒽酮衍生物作为潜在的抗癌药。
6. Structure–Activity Relationship Study of Acyclic Terpenes in Blood Glucose Levels: Potential α-Glucosidase and Sodium Glucose Cotransporter (SGLT-1) Inhibitors [O] . Miguel Valdes, Fernando Calzada, Jessica Mendieta-Wejebe 2019

机译：血糖水平上无环萜烯的结构-活性关系研究：潜在的α-葡萄糖苷酶和钠葡萄糖共转运蛋白（SGLT-1）抑制剂
7. TheN-Benzyl Derivative of the Glucosidase Inhibitor 1-Deoxynojirimycin Shows a Prolonged Half-Life and a More Complete Oral Absorption in the Rat Compared with theN-Methyl Analog [O] . Esther D. Faber, Leon A. G. M. van den Broek, Ellen E. Z. Oosterhuis, 1998

机译：然后葡萄糖苷酶抑制剂1-脱苏昔尼霉素的苄基衍生物显示延长的半衰期和大鼠中更完全的口服吸收与然后 - 甲基类似物相比
8. Chemotherapeutic Potential of G1 Cell Cycle Inhibitor Indole-3-Carbinol and Its More Potent N-Alkoxy Derivatives in Human Breast Cancer Xenografts in Mice [R] . Kerekatte, V. S. , Firestone, G. 2004

机译：G1细胞周期抑制剂吲哚-3-甲醇及其更有效的N-烷氧基衍生物在小鼠人乳腺癌异种移植物中的化疗潜力

Acyclic Analolgues of Glucosamidine, 1-Deoxynojirimycin and N-(1,3-Dihydroxyprop-2-yl)Derivative of Valiolamine as Potential Glucosidase Inhibitors

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