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Twin studies in pediatric depression.

机译:小儿抑郁症的双胞胎研究。

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摘要

Pediatric depression is an important clinical problem that is known to be familial. Twin studies have been used not only to examine the genetic etiology of depression but also to investigate developmental changes and gender effects, the relationship of depression with anxiety, and increasingly, the interplay of genetic liability with environmental risk factors. There is evidence that pediatric depression symptom scores and clinical depression are genetically influenced, but results from different twin studies have varied. These studies also have demonstrated the important contribution of environmental risk factors. Some of the differences in findings may be caused partly by clinical heterogeneity, developmental differences in etiology (stronger genetic influences for depression symptom scores in adolescence than in childhood), and measurement issues, such as who rates the symptoms.
机译:小儿抑郁症是一个重要的临床问题,已知是家族性的。孪生研究不仅用于检查抑郁症的遗传病因,还用于研究发育变化和性别效应,抑郁症与焦虑的关系,以及越来越多的遗传责任与环境危险因素之间的相互作用。有证据表明,小儿抑郁症症状评分和临床抑郁症具有遗传影响,但是来自不同双胞胎研究的结果却有所不同。这些研究还证明了环境危险因素的重要贡献。研究结果的某些差异可能部分是由于临床异质性,病因学上的发育差异(与儿童时期相比,青春期抑郁症状评分的遗传影响更强)以及测量问题,例如谁对症状进行评分。

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