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Psychopharmacology in pediatric critical care.

机译:儿科重症监护中的心理药理学。

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Psychopharmacologic treatment in pediatric critical care requires a careful child or adolescent psychiatric evaluation, including a thorough review of the history of present illness or injury, any current or pre-existing psychiatric disorder, past history, and laboratory studies. Although there is limited evidence to guide psychopharmacologic practice in this setting, psychopharmacologic treatment is increasing in critical care, with known indications for treatment, benefits, and risks; initial dosing guidelines; and best practices.Treatment is guided by the knowledge bases in pediatric physiology, psycho-pharmacology, and treatment of critically ill adults. Pharmacologic considerations include pharmacokinetic and pharmcodynamic aspects of specific drugs and drug classes, in particular elimination half-life, developmental considerations, drug interactions, and adverse effects. Evaluation and management of pain is a key initial step, as pain may mimic psychiatric symptoms and its effective treatment canameliorate them. Patient comfort and safety are primary objectives for children who are acutely ill and who will survive and for those who will not. Judicious use of psychopharmacolgic agents in pediatric critical care using the limited but growing evidence base and a clinical best practices collaborative approach can reduce anxiety,sadness, disorientation, and agitation; improve analgesia; and save lives of children who are suicidal or delirious. In addition to pain, other disorders or indications for psychopharmacologic treatment are affective disorders;PTSD; post-suicide attempt patients; disruptive behavior disorders (especially ADHD); and adjustment, developmental, and substance use disorders. Treating children who are critically ill with psychotropic drugs is an integral component of comprehensive pediatric critical care in relieving pain and delirium; reducing inattention or agitation or aggressive behavior;relieving acute stress, anxiety, or depression; and improving sleep and nutrition. In palliativecare, psychopharmacology is integrated with psychologicapproaches to enhance children's comfort at the end of life. Defining how best to prevent the adverse consequences of suffering and stress in pediatric critical care is a goal for protocols and for new psychopharmacologic research [23,153].
机译:儿科重症监护室的心理药物治疗需要对儿童或青少年进行仔细的精神病学评估,包括对当前疾病或受伤的病史,任何当前或先前存在的精神病,过去的病史以及实验室研究进行彻底的回顾。尽管在这种情况下指导心理药物治疗实践的证据有限,但在重症监护中心理药物治疗正在增加,已知治疗,益处和风险的指征;初始剂量指导;治疗以小儿生理学,心理药理学和重症成人治疗的知识基础为指导。药理学方面的考虑包括特定药物和药物类别的药代动力学和药效学方面,尤其是消除半衰期,发展方面的考虑,药物相互作用和不良反应。疼痛的评估和管理是关键的初始步骤,因为疼痛可以模仿精神病症状,其有效治疗可以缓解这些症状。患者的舒适度和安全性是重症儿童,能够生存和不会生存的儿童的主要目标。使用有限但不断增长的证据基础和临床最佳实践协作方法,明智地在儿科重症监护室使用心理药物,可以减少焦虑,悲伤,迷失方向和躁动;改善镇痛;并挽救自杀或精神错乱的孩子的生命。除疼痛外,其他障碍或心理药物治疗的适应症包括情感障碍;自杀未遂患者;破坏性行为障碍(尤其是多动症);以及适应,发育和物质使用障碍。用精神药物治疗重症儿童是缓解疼痛和del妄的全面儿科重症监护不可或缺的组成部分;减少注意力不集中或躁动或攻击性行为;减轻急性压力,焦虑或沮丧;并改善睡眠和营养。在姑息治疗中,将心理药理学与心理治疗方法结合在一起,以提高孩子生命终结时的舒适感。定义如何最好地预防小儿重症监护室遭受痛苦和压力的不良后果是方案和新的心理药理研究的目标[23,153]。

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