Recognizing and monitoring adverse events of second-generation antipsychotics in children and adolescents.

Correll CU; Penzner JB; Parikh UH; Mughal T; Javed T; Carbon M; Malhotra AK

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Recognizing and monitoring adverse events of second-generation antipsychotics in children and adolescents.

机译：识别和监测儿童和青少年的第二代抗精神病药的不良事件。

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Although second-generation antipsychotics (SGAs) are used increasingly in children and adolescents, data on the effectiveness and safety in pediatric populations are still sparse. Much of the safety information is derived from studies conducted in adults. This derivation is problematic because children and adolescents are exposed to SGAs during a phase of unparalleled physical and psychologic development that can affect pharmacokinetic and pharmacodynamic drug actions, efficacy, and side-effect patterns. This article presents an overview of SGA-related side effects in children and adolescents and strategies to monitor health outcomes effectively in youngsters receiving SGAs.

机译：尽管第二代抗精神病药（SGA）在儿童和青少年中的使用越来越多，但有关儿童人群的有效性和安全性的数据仍然很少。许多安全信息来自成年人的研究。这种推导是有问题的，因为儿童和青少年在无与伦比的身体和心理发展阶段会接触到SGA，这可能会影响药代动力学和药效学药物的作用，功效和副作用模式。本文概述了儿童和青少年中SGA相关的副作用，以及有效监测接受SGA的年轻人健康状况的策略。

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《Child and adolescent psychiatric clinics of North America》 |2006年第1期|共30页
作者
Correll CU; Penzner JB; Parikh UH; Mughal T; Javed T; Carbon M; Malhotra AK;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Adolescent; Antipsychotic Agents; Basal Ganglia Diseases; Body Mass Index; 抗精神病剂; 基底神经节疾病; 人体质量指数; 儿童; 精神障碍; 催乳素;

机译：Adolescent;Antipsychotic Agents;Basal Ganglia Diseases;Body Mass Index;抗精神病剂;基底神经节疾病;人体质量指数;儿童;精神障碍;催乳素;

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1. Recognizing and monitoring adverse events of second-generation antipsychotics in children and adolescents. [J] . Correll CU, Penzner JB, Parikh UH, Child and adolescent psychiatric clinics of North America . 2006,第1期

机译：识别和监测儿童和青少年的第二代抗精神病药的不良事件。
2. Multiple antipsychotic use associated with metabolic and cardiovascular adverse events in children and adolescents. [J] . Correll CU Evidence-based mental health . 2009,第3期

机译：与儿童和青少年的代谢和心血管不良事件相关的多种抗精神病药物使用。
3. Hyperprolactinemia-related adverse events associated with antipsychotic treatment in children and adolescents. [J] . Jerrell JM, Bacon J, Burgis JT The Journal of adolescent health: official publication of the Society for Adolescent Medicine . 2009,第1期

机译：与抗精神病药物治疗相关的高泌乳素血症相关不良事件在儿童和青少年中发生。
4. Sentinel Event Methods for Monitoring Unanticipated Adverse Events [C] . Peter A. Lachenbruch, Janet Wittes International Conference on Statistics in Health Sciences . 2007

机译：监测意外不良事件的Sentinel事件方法
5. Digital pharmacovigilance: The MedWatcher system for monitoring adverse events through automated processing of Internet social media and crowdsourcing. [D] . Freifeld, Clark C. 2014

机译：数字药物警戒：MedWatcher系统，用于通过自动处理Internet社交媒体和众包来监视不良事件。
6. Monitoring of metabolic adverse events of second-generation antipsychotics in a naive paediatric population followed in mental health outpatient and inpatient clinical settings: MEMAS prospective study protocol [O] . Marie-Line Menard, Drigissa Ilies, Pascale Abadie, 2021

机译：在幼稚的儿科人群中监测第二代抗精神病药的代谢不良事件伴随着心理健康门诊和住院性临床环境：MEMAS前瞻性研究方案
7. Second-generation antipsychotic drugs and short-term somatic serious adverse events: a systematic review and meta-analysis [O] . Johannes Schneider-Thoma, Orestis Efthimiou, Irene Bighelli, 2019

机译：第二代抗精神病药和短期躯体严重不良事件：系统审查和荟萃分析
8. First- and Second-Generation Antipsychotics for Children and Young Adults. Systematic Review Update Executive Summary. Comparative Effectiveness Review Number 184. [R] . 2017

机译：儿童和青少年的第一代和第二代抗精神病药物。系统评价更新执行摘要。比较效力审查编号184。

Recognizing and monitoring adverse events of second-generation antipsychotics in children and adolescents.

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