ALPHA,ALPHA'-DIOXOTHIONES .2. ASYMMETRIC DIELS-ALDER REACTIONS OF CHIRAL NON-RACEMIC ALPHA,ALPHA'-DIOXOTHIONES

Boccardo G.; Giuntini M.; Menichetti S.; Nativi C.; Capozzi G.

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ALPHA,ALPHA'-DIOXOTHIONES .2. ASYMMETRIC DIELS-ALDER REACTIONS OF CHIRAL NON-RACEMIC ALPHA,ALPHA'-DIOXOTHIONES

机译：阿尔法，阿尔法-二氧噻吩酮2。手性非自由基阿尔法，阿尔法-二氧杂环丁酮的不对称狄尔斯-阿尔德反应

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Chiral non-racemic alpha,alpha'-dioxothiones 2a-g and 17 are obtained from chiral beta-ketoesters using the phthalimidesulfenyl chloride 1 as key reagent. The ability of these thiones to discriminate between the enantiotopic faces of several dienophiles has been evaluated, The best diastereoisomeric excesses (67-80%) were obtained when the alpha-acyl thiones were involved as electron-poor dienes in inverse electron demand Diels-Alder reactions with electron-rich styrenes as dienophiles. The possibility to obtain thiones bearing two,chiral groups as-well as the reactions where the alpha-acyl thiones 2 participate as dienophiles are also shown. (C) 1997 Elsevier Science Ltd. [References: 22]

机译：手性非外消旋的α，α'-二氧噻吩类化合物2a-g和17是由邻苯二甲酰亚胺基氯化亚砜1作为关键试剂，从手性β-酮酸酯获得的。评估了这些硫酮区分几种亲二烯体的对映体表面的能力。当α-酰基硫酮作为逆电子需求的电子贫二烯参与时，可获得最佳非对映异构体过量（67-80％）。与富电子苯乙烯作为亲二烯体反应。还显示了获得带有两个手性基团的硫酮的可能性以及α-酰基硫酮2作为亲二烯体参与的反应。（C）1997 Elsevier Science Ltd. [参考：22]

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《Tetrahedron》 |1997年第51期|共12页
作者
Boccardo G.; Giuntini M.; Menichetti S.; Nativi C.; Capozzi G.;
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正文语种 eng
中图分类有机化学;
关键词
A-ring precursor; Beta-keto-esters; Vinyl ethers; D-3 steroids; Acid; Cycloaddition; Configuration; 2-pyrone; Chloride;

机译：A环前体;β-酮酸酯;乙烯基醚;D-3类固醇;酸;环加成;构型;2-吡喃酮;氯化物;

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1. ALPHA,ALPHA'-DIOXOTHIONES .2. ASYMMETRIC DIELS-ALDER REACTIONS OF CHIRAL NON-RACEMIC ALPHA,ALPHA'-DIOXOTHIONES [J] . Boccardo G., Giuntini M., Menichetti S., Tetrahedron . 1997,第51期

机译：阿尔法，阿尔法-二氧噻吩酮2。手性非自由基阿尔法，阿尔法-二氧杂环丁酮的不对称狄尔斯-阿尔德反应
2. #alpha# #alpha#'-Dioxothiones, III Regio- and Stereoselective Ene and Tandem "Ene-Cycloaddition" Reactions of 2,4-Dioxopentane-3-thione [J] . Giuseppe Capozzi, Marco Fragai, Stefano Menichetti, European journal of organic chemistry . 1999,第12期

机译：＃alpha＃#alpha＃'-Dioxothiones，III区域和立体选择性烯和2,4-二氧戊烷-3-硫酮的串联“烯环加成”反应
3. #alpha#- Oxothiones, IV Electrophilic Substitution of Phenols wiht #alpha#,#alpha#'-Dioxothiones and orhto-Thioquinones [J] . Giuseppe Capozzi, Stefano Menichetti, Cristina Nativi European journal of organic chemistry . 2000,第21期

机译：＃alpha＃-Oxothiones，用#alpha＃，＃alpha＃'-Dioxothiones和邻-硫代醌对苯酚进行IV亲电取代
4. Enantioselective 2+2 Cycloaddition Reaction of 1-Methoxyallenylsilane with alpha-Imino Ester:Chiral Synthesis of alpha,beta-Unsaturated Acylsilanes [C] . Kazunori Daidouji, Kohei Fuchibe, Takahiko Akiyama Symposium on Organometallic Chemistry . 2003

机译：1-甲氧基亚乙烷与α-亚氨基酯的映选择性2 + 2环加入反应：α，β-不饱和酰基硅烷的手性合成
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机译：第一部分：利塞膦酸盐双环类似物的不对称合成，作为双膦酸盐类抗骨质疏松药和潜在更有效的抗骨质疏松药作用机理的分子探针。第二部分使用Bestmann内酯从常见手性助剂轻松制备和官能化手性稳定化的叶基及其在Wittig反应中的用途。第三部分不对称有机催化：1.醛的α-羟基化研究； 2.合成新的基于樟脑的α-氨基四唑有机催化剂。
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机译：人类乳头瘤病毒E6和E7的系统发育和多态性：alpha-9（HPV1631335258）alpha-5（HPV51）alpha-6（HPV5366）alpha-7（HPV1839 来自上海的女性中的5968）和alpha-10（HPV644）
7. Asymmetric Diels-Alder Reactions Using Chiral alpha;, beta;-Unsaturated Sulfoxides and Its Application to Natural Products Synthesis [O] . Yoshitsugu ARAI 1994

机译：使用手性α，β-不饱和亚砜的不对称Diels - alder反应及其在天然产物合成中的应用
8. Asymmetric Reduction of Alpha-Keto Esters with Potassium 9-O-(1,2:5,6-Di-O-Isopropylidene-Alpha-D-Glucofuranosyl)-9- Boratabicyclo(3.3.1)Nonane. Chiral Synthesis of Alpha-Hydroxy Esters with Optical Purity Approaching 100% ee [R] . Brown, H. C., Cho, B. T., Park, W. S. 1986

机译：用9-O-（1,2：5,6-二-O-异亚丙基-α-D-葡呋喃糖基）-9-硼代三环（3.3.1）壬烷不对称还原α-酮基酯。具有光学纯度接近100％ee的α-羟基酯的手性合成

ALPHA,ALPHA'-DIOXOTHIONES .2. ASYMMETRIC DIELS-ALDER REACTIONS OF CHIRAL NON-RACEMIC ALPHA,ALPHA'-DIOXOTHIONES

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