...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Differential putaminal morphology in Huntington's disease, frontotemporal dementia and Alzheimer's disease.
【24h】

Differential putaminal morphology in Huntington's disease, frontotemporal dementia and Alzheimer's disease.

机译：亨廷顿氏病，额颞叶痴呆和阿尔茨海默氏病的差异性腹膜形态学。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Direct neuronal loss or deafferentation of the putamen, a critical hub in corticostriatal circuits, may result in diverse and distinct cognitive and motoric dysfunction in neurodegenerative disease. Differential putaminal morphology, as a quantitative measure of corticostriatal integrity, may thus be evident in Huntington's disease (HD), Alzheimer's disease (AD) and frontotemporal dementia (FTD), diseases with differential clinical dysfunction. Methods: HD (n = 17), FTD (n = 33) and AD (n = 13) patients were diagnosed according to international consensus criteria and, with healthy controls (n = 17), were scanned on the same MRI scanner. Patients underwent brief cognitive testing using the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG). Ten MRI scans from this dataset were manually segmented as a training set for the Adaboost algorithm, which automatically segmented all remaining scans for the putamen, yielding the following subset of the data: 9 left and 12 right putamen segmentations for AD; 25 left and 26 right putamina for FTD; 16 left and 15 right putamina for HD; 12 left and 12 right putamina for controls. Shape analysis was performed at each point on the surface of each structure using a multiple regression controlling for age and sex to compare radial distance across diagnostic groups. Results: Age, but not sex and intracranial volume (ICV), were significantly different in the segmentation subgroups by diagnosis. The AD group showed significantly poorer performance on cognitive testing than FTD. Mean putaminal volumes were HD < FTD < AD ≤ controls, controlling for age and ICV. The greatest putaminal shape deflation was evident in HD, followed by FTD, in regions corresponding to the interconnections to motoric cortex. Conclusions: Differential patterns of putaminal atrophy in HD, FTD and AD, with relevance to corticostriatal circuits, suggest the putamen may be a suitable clinical biomarker in neurodegenerative disease.
机译：目的：直接神经元损失或壳灰质剥夺是皮质类固醇循环的关键枢纽，可能导致神经退行性疾病发生多种多样的认知和运动功能障碍。因此，差异性的腹膜形态学可以作为皮质骨皮质完整性的定量指标，在具有不同的临床功能障碍的亨廷顿氏病（HD），阿尔茨海默氏病（AD）和额颞痴呆（FTD）中可能很明显。方法：按照国际共识标准诊断HD（n = 17），FTD（n = 33）和AD（n = 13）患者，并在健康对照（n = 17）的情况下，在同一台MRI扫描仪上进行扫描。使用神经精神病科认知评估工具（NUCOG）对患者进行简短的认知测试。将来自该数据集的十次MRI扫描手动分割为Adaboost算法的训练集，该训练集会自动分割所有剩余的核壳扫描，产生以下数据子集：AD的9个左核壳和12个右核的核壳; FTD左25和右26 HD左16和右15左侧12个左手和右侧12个右手。使用控制年龄和性别的多元回归在每个结构的表面上的每个点进行形状分析，以比较诊断组之间的径向距离。结果：根据诊断结果，细分人群的年龄，性别和颅内容积（ICV）没有显着差异。 AD组在认知测试中的表现明显比FTD差。平均put体积为HD

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号