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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Delirium as a symptom of quetiapine poisoning.
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Delirium as a symptom of quetiapine poisoning.

机译：妄是喹硫平中毒的症状。

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Data on quetiapine overdose are sparse in the literature [1]. Most of these limit the neurological and mental state symptoms of overdose to sedation, drowsiness and loss of consciousness [2]. Few sources report delirium as a likely consequence of overdoses with quetiapine alone. Quetiapine is an atypical antipsychotic used in the management of schizophrenia and bipolar I disorder, and is used off-label for a variety of other purposes, including insomnia, anxiety and personality disorders. The antipsychotic effect of quetiapine is thought to be mediated through the antagonist activity at the dopamine (D1 and D2) and serotonin (5HT-1 and 5 HT-2) receptors. In addition, quetiapine has an antagonistic effect on the histamine H1 receptor. This is thought to be responsible for the sedative effect of the drug. Other than sedation, quetiapine is a popular drug because of its relatively benign side-effect profile with regard to extra-pyramidal symptoms and serum prolactin level elevation.
机译：喹硫平过量的数据在文献中很少[1]。这些中的大多数将过量的神经和精神状态症状限制为镇静，嗜睡和意识丧失[2]。很少有资料表明del妄是过量使用喹硫平的可能结果。喹硫平是一种非典型的抗精神病药，用于精神分裂症和双相性I障碍的治疗，并已用于多种其他目的，包括失眠，焦虑和人格障碍。喹硫平的抗精神病作用被认为是通过对多巴胺（D1和D2）和血清素（5HT-1和5 HT-2）受体的拮抗剂活性介导的。另外，喹硫平对组胺H1受体具有拮抗作用。认为这是造成药物镇静作用的原因。除镇静外，喹硫平是一种受欢迎的药物，因为它在锥体束外症状和血清催乳素水平升高方面具有相对较好的副作用。

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