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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Is schizophrenia the price of human central nervous system complexity?
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Is schizophrenia the price of human central nervous system complexity?

机译：精神分裂症是人类中枢神经系统复杂性的代价吗？

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摘要

The purpose of the present study was to determine if there is evidence to support the hypothesis that schizophrenia is a human-specific disorder associated with the need for highly complex central nervous system (CNS) development. A review was therefore undertaken of published literature relevant to the identification of human-specific CNS development. There was no clear evidence found at the macroscopic, microscopic or molecular level that suggests unique changes have occurred in the evolution of the human CNS. Rather, highly significant changes in the size of the frontal lobe, increases in numbers of specific cell types, changes in gene expression and changes in genome sequence all seem to be involved in the evolution of the human CNS. Human-specific changes in CNS development are wide ranging. The modification in CNS structure and function that has resulted from these changes affects many pathways and behaviours that appear to be also affected in subjects with schizophrenia. Therefore there is evidence to support the hypothesis that schizophrenia is a disease that develops because of derangements to human-specific CNS functions that have emerged since our species diverged from non-human primates.
机译：本研究的目的是确定是否有证据支持精神分裂症是与高度复杂的中枢神经系统（CNS）发育相关的人类特异性疾病的假说。因此，对与鉴定人特异性中枢神经系统发育有关的已发表文献进行了回顾。在宏观，微观或分子水平上都没有发现明确的证据表明人类中枢神经系统的进化发生了独特的变化。相反，额叶大小的高度显着变化，特定细胞类型的数量增加，基因表达的变化和基因组序列的变化似乎都参与了人类CNS的进化。中枢神经系统发展中因人而异的变化范围广泛。由这些变化引起的中枢神经系统结构和功能的改变会影响精神分裂症患者的许多途径和行为，这似乎也受到影响。因此，有证据支持以下假设：精神分裂症是一种疾病，由于我们物种从非人类灵长类动物分化而出现的人类特异性中枢神经系统功能紊乱而发展。

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