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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Surface initiated molecularly imprinted polymer films: a new approach in chiral capillary electrochromatography
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Surface initiated molecularly imprinted polymer films: a new approach in chiral capillary electrochromatography

机译：表面引发的分子印迹聚合物膜：手性毛细管电色谱的新方法

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摘要

A new generation of imprinted composite particles was tested as capillary electrochromatography stationary phse. Silica particles characterised by a well defined particle size (10 #mu#m diameter), shape and pore system (1000 A) were modified with an azoinitiator and subsequently used to graft molecularly imprinted polymers targeted to bind L-phenyl-alanine anilide, Fused silica capillaries were packed over a length corresponding to 8 cm, using a pneumatic amplification pump, and the stationary phase thus obtained was tested with respect to its electrochromatographic performance. The electroendosmotic flow mobility was evaluated with respect to both the different content of polymer on the silica particle surface and different operating pH values. The dependence of various parameters, namely the analyte concentration, the polymer layer thickness and the pH of the mobile phase on the enantioselectivity was investigated. These CEC capillaries showed enantioselectivity comparable with that showed in LC, and exhibited improved performance in temrs of plate number N_1 (approx 13 000), selectivity #alpha# (approx 1.5), analysis time (<3 min), inter-intraday and intercapillary reproducibility. We expect this approach to result in a new generation of robust, tailor-made chiral or affinity stationary phases for CEC.
机译：测试了新一代压印复合颗粒作为毛细管电色谱固定相。具有良好定义的粒径（直径10＃μm），形状和孔系统（1000 A）的二氧化硅颗粒用偶氮引发剂改性，随后用于接枝旨在结合L-苯基-丙氨酸苯胺的分子印迹聚合物，熔融使用气动放大泵将二氧化硅毛细管填充至对应于8 cm的长度，并测试由此获得的固定相的电色谱性能。相对于二氧化硅颗粒表面上聚合物的不同含量和不同的操作pH值，评估了电渗透流动性。研究了各种参数，即分析物浓度，聚合物层厚度和流动相的pH对映选择性的依赖性。这些CEC毛细管的对映选择性与LC相当，并且在板数N_1（约13000），选择性＃alpha＃（约1.5），分析时间（<3分钟），盘中和毛细管间表现出更好的性能。重现性。我们希望这种方法能够为CEC带来新一代的稳健，量身定制的手性或亲和固定相。

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