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Mechanism of analgesic effect of placebo

机译:安慰剂的镇痛作用机理

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摘要

IT is well established that placebos induce a significant response when patients are unaware that they are receiving a placebo as opposed to a pharmacologically active substance in double blind, placebo-controlled clinical trials. However, what is not known so well is the mechanisrn(s) by which placebos exert their effects. Patients' expectations for improvement, also referred to as 'response expectancies', are thought to be one of the central mechanisms responsible for placebo effects. While this concept appears to be reasonable it does not explain actually how response expectancies occur.
机译:众所周知,在双盲,安慰剂对照的临床试验中,当患者不知道自己正在接受安慰剂而不是药理活性物质时,安慰剂会引起显着反应。然而,还不太清楚的是安慰剂发挥作用的机制。患者对改善的期望,也称为“反应期望”,被认为是负责安慰剂作用的主要机制之一。尽管这个概念似乎是合理的,但实际上并不能解释预期响应如何发生。

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