...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The clinical journal of pain >Effect of postoperative analgesia on energy metabolism and role of cyclooxygenase-2 inhibitors for postoperative pain management after abdominal surgery in adults
【24h】

Effect of postoperative analgesia on energy metabolism and role of cyclooxygenase-2 inhibitors for postoperative pain management after abdominal surgery in adults

机译：术后镇痛对成人腹部手术后能量代谢的影响以及环氧合酶2抑制剂在术后疼痛管理中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: It is questionable whether the stress response to surgery is necessary. The objective of this study was to evaluate the effectiveness of postoperative analgesia on energy metabolism and compare cyclooxygenase-2 selective inhibitor with tramadol in postoperative pain management after major abdominal surgery. METHODS: A total of 112 patients undergoing major abdominal surgery were randomly assigned to one of the 4 treatment groups before surgery. Then, patients were scheduled to receive different analgesic drugs after surgery: group parecoxib/control received intravenous parecoxib (40 mg bid) for 3 days; group parecoxib/celecoxib received intravenous parecoxib (40 mg bid) for 3 days and continued oral celecoxib (0.2 mg bid) for 4 days; group tramadol/control received intravenous tramadol (0.1 g tid) for 3 days; and group tramadol/tramadol received intravenous tramadol (0.1 g tid) for 3 days and continued oral tramadol (0.1 g tid) for 4 days. RESULTS: Group tramadol/tramadol showed much lower rest energy expenditure 1 week after surgery (P<0.05). The measured rest energy expenditure was significantly lower in patients treated with analgesic drugs administered from day 4 to 7 after surgery relative to control group (P<0.01). From the fourth day after surgery, groups parecoxib/celecoxib and tramadol/tramadol showed significantly lower pain intensity ratings compared with groups parecoxib/control and tramadol/control during leg raising (P<0.05). CONCLUSIONS: These results confirm that sufficient postoperative analgesia may be efficient to reduce some of the stress responses to operative trauma. In addition, intravenous parecoxib (40 mg bid) followed by oral celecoxib (0.2 g bid) is as effective as intravenous tramadol (0.1 g tid) with continued oral tramadol (0.1 g tid) after major abdominal surgery.
机译：目的：是否需要对手术进行压力反应值得怀疑。这项研究的目的是评估术后镇痛对能量代谢的有效性，并比较环氧合酶2选择性抑制剂和曲马多在腹部大手术后的疼痛处理中的作用。方法：总共112例接受腹部大手术的患者在手术前被随机分为4个治疗组之一。然后，患者计划在手术后使用不同的镇痛药：帕瑞昔布组/对照组接受静脉帕瑞昔布（40 mg bid）治疗3天; parecoxib / celecoxib组接受静脉parecoxib（40 mg bid）3天，并继续口服celecoxib（0.2 mg bid）4天;曲马多/对照组接受静脉曲马多（0.1 g tid）3天;曲马多/曲马多治疗组接受静脉曲马多（0.1 g tid）3天，继续口服曲马多（0.1 g tid）4天。结果：曲马多/曲马多组术后1周的静息能量消耗低得多（P <0.05）。与对照组相比，在手术后第4天至第7天服用镇痛药的患者测得的静息能量消耗显着降低（P <0.01）。从手术后第四天开始，帕瑞考昔/塞来昔布和曲马多/曲马多组的腿部抬高过程中疼痛强度等级明显低于帕瑞昔布/对照组和曲马多/对照组（P <0.05）。结论：这些结果证实，充分的术后镇痛可能有效地减少了一些对手术创伤的压力反应。另外，静脉帕瑞昔布（40 mg bid），随后口服塞来昔布（0.2 g bid）与大腹部手术后静脉曲马多（0.1 g tid）和持续口服曲马多（0.1 g tid）一样有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号