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首页> 外文期刊>The Breast : >Pathological and mammographic prognostic factors for screen detected cancers in a multi-centre randomised, controlled trial of mammographic screening in women from age 40 to 48 years
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Pathological and mammographic prognostic factors for screen detected cancers in a multi-centre randomised, controlled trial of mammographic screening in women from age 40 to 48 years

机译：在一项多中心随机对照试验中，对年龄在40至48岁之间的女性进行乳腺筛查的多中心随机对照试验，用于筛查检测到的癌症的病理和乳腺X线预后因素

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摘要

Aim: To assess pathological and radiological prognostic factors for cancers detected by screening within a multi-centre RCT trial of mammographic screening of younger women. Method: The survival of 232 women with screen detected invasive cancer was ascertained. Data on invasive cancer size, histological grade, nodal status, vascular invasion, mammographic spiculation, comedo calcification and mammographic background were assessed. Kaplan-Meier and Cox proportional hazards methods were used to examine survival. Results: Univariate analysis indicated that women with cancers with the following features had poorer survival; ≥30 mm, histologically grade 3, heavily node positive (4 or more positive nodes), vascular invasion positive and displaying mammographic comedo calcification. In a multivariate model survival remained poorer in women with four or more nodes positive (HR 8.36, 95% CI 2.31, 30.17) and in those with comedo calcification (HR 3.00,95% CI 1.13, 7.99). Conclusion: Nodal status and the presence of mammographic comedo calcification have independent prognostic significance in young women with screen detected cancer.
机译：目的：通过对年轻女性进行乳房X光检查的多中心RCT试验中的筛查，评估发现的癌症的病理和放射学预后因素。方法：确定232例经筛查发现浸润性癌的妇女的存活率。评估了浸润性癌大小，组织学等级，淋巴结状态，血管浸润，乳腺X线摄影性结石，粉刺钙化和乳腺X线摄影背景的数据。 Kaplan-Meier和Cox比例风险方法用于检查生存率。结果：单因素分析表明，患有以下特征的癌症妇女生存率较差; ≥30 mm，组织学等级3，重度淋巴结阳性（4个或更多阳性淋巴结），血管浸润阳性，并表现出乳腺X线摄影钙化。在多变量模型中，具有四个或更多淋巴结阳性的女性（HR 8.36，95％CI 2.31，30.17）和粉刺钙化的女性（HR 3.00,95％CI 1.13，7.99）的存活率仍然较低。结论：淋巴结状况和乳腺X线摄影钙化的存在对筛查癌症的年轻女性具有独立的预后意义。

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