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首页> 外文期刊>The British journal of psychiatry : >Impact of childhood abuse on the clinical course of bipolar disorder.
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Impact of childhood abuse on the clinical course of bipolar disorder.

机译：儿童虐待对双相情感障碍临床病程的影响。

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BACKGROUND: Few investigations have examined the impact of childhood trauma, and domains of childhood abuse, on outcome in bipolar disorder. AIMS: To evaluate the prevalence and subtypes of childhood abuse reported by adult patients with bipolar disorder and relationship to clinical outcome. METHOD: Prevalence rates of childhood abuse were retrospectively assessed and examined relative to illness complexity in a sample of 100 patients at an academic specialty centre for the treatment of bipolar disorder. RESULTS: Histories of severe childhood abuse were identified in about half of the sample and were associated with early age at illness onset. Abuse subcategories were strongly inter-related. Severe emotional abuse was significantly associated with lifetime substance misuse comorbidity and past-year rapid cycling. Logistic regression indicated a significant association between lifetime suicide attempts and severe childhood sexual abuse. Multiple forms of abuse showed a graded increase in risk for both suicide attempts and rapid cycling. CONCLUSIONS: Severe childhood trauma appears to have occurred in about half of patients with bipolar disorder, and may lead to more complex psychopathological manifestations.
机译：背景：很少有研究检查儿童创伤和儿童虐待对双相情感障碍结局的影响。目的：评估双相情感障碍成年患者报告的儿童期虐待的患病率和亚型以及与临床结局的关系。方法：回顾性评估和审查了在学术专科中心治疗双相情感障碍的100名患者中，儿童疾病的患病率与疾病复杂性的关系。结果：大约一半的样本中发现了严重的儿童虐待史，并与发病初期的年龄有关。滥用子类别之间密切相关。严重的情感虐待与终生滥用药物合并症和过去一年的快速骑自行车显着相关。 Logistic回归表明终身自杀未遂与严重的儿童性虐待之间存在显着关联。多种形式的虐待显示自杀未遂和快速骑自行车的风险呈逐步增加的趋势。结论：大约一半的躁郁症患者似乎发生了严重的儿童期创伤，并可能导致更复杂的心理病理表现。

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