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首页> 外文期刊>The British journal of psychiatry : >St John's wort for depression: meta-analysis of randomised controlled trials.
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St John's wort for depression: meta-analysis of randomised controlled trials.

机译：抑郁症的圣约翰草：随机对照试验的荟萃分析。

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摘要

BACKGROUND: Extracts of Hypericum perforatum (St John's wort) are widely used to treat depression. Evidence for its efficacy has been criticised on methodological grounds. AIMS: To update evidence from randomised trials regarding the effectiveness of Hypericum extracts. METHODS: We performed a systematic review and meta-analysis of 37 double-blind randomised controlled trials that compared clinical effects of Hypericum monopreparation with either placebo or a standard antidepressant in adults with depressive disorders. RESULTS: Larger placebo-controlled trials restricted to patients with major depression showed only minor effects over placebo, while older and smaller trials not restricted to patients with major depression showed marked effects. Compared with standard antidepressants Hypericum extracts had similar effects. CONCLUSIONS: Current evidence regarding Hypericum extracts is inconsistent and confusing. In patients who meet criteria for major depression, several recent placebo-controlled trials suggest that Hypericum has minimal beneficial effects while other trials suggest that Hypericum and standard antidepressants have similar beneficial effects.
机译：背景：贯叶连翘提取物（圣约翰草）被广泛用于治疗抑郁症。其功效的证据已从方法论的角度受到批评。目的：更新有关贯叶连翘提取物有效性的随机试验证据。方法：我们进行了37项双盲随机对照试验的系统评价和荟萃分析，比较了贯叶连翘单药制剂与安慰剂或标准抗抑郁药在抑郁症成人中的临床效果。结果：仅限于重度抑郁症患者的较大安慰剂对照试验仅显示出比安慰剂轻微的作用，而不限于重度抑郁症患者的较大和较小的试验显示出明显的作用。与标准抗抑郁药相比，贯叶连翘提取物具有相似的作用。结论：有关贯叶连翘提取物的当前证据不一致且令人困惑。在符合重度抑郁症标准的患者中，最近的几项安慰剂对照试验表明金丝桃属植物具有最小的有益作用，而其他试验表明金丝桃属植物和标准抗抑郁药具有相似的有益作用。

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