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首页> 外文期刊>The British journal of psychiatry : >Brain white-matter hyperintensities and treatment outcome in major depressive disorder.
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Brain white-matter hyperintensities and treatment outcome in major depressive disorder.

机译：重度抑郁症患者的脑白质高信号和治疗结果。

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BACKGROUND: An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS: To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. METHOD: We assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressant treatment. We also assessed hyperintensities in 35 matched controls. RESULTS: We found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertensionand age and withtotal cardiovascular risk score. CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression.
机译：背景：在重度抑郁症中，脑白质高信号的发生率有所增加，但这种高信号对治疗结果的影响仍存在争议。目的：探讨脑白质高信号与心血管疾病危险因素及年轻抑郁症年轻人治疗结果的关系。方法：我们在开始抗抑郁治疗之前，评估了84名重度抑郁症患者的脑白质高信号和心血管危险因素。我们还评估了35个匹配对照中的高强度。结果：我们发现抑郁症组和对照组之间的白质高强度患病率没有显着差异。左半球皮质下血流过多与较低的治疗反应率相关。我们发现总体高强度测量与临床结果之间没有相关性。脑白质高强度与高血压，年龄和总心血管风险评分有关。结论：左半球皮层下白色物质高信号（但在其他脑区除外）可能与严重抑郁症患者抗抑郁治疗反应差有关。

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