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首页> 外文期刊>The British journal of psychiatry : >Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume.
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Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume.

机译：精神分裂症和颞叶不对称。尸体组织的尸体解剖研究。

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BACKGROUND: A previous report by Crow of a left-sided increase in temporal horn volume in schizophrenia implies a left-sided loss of tissue. AIMS: To elucidate the structural nature of schizophrenia. METHOD: The volume of grey matter in the temporal pole and inferior, middle and superior temporal gyri was measured, in addition to the total volume of grey and white matter, in the temporal lobes of the brains of 29 patients with schizophrenia and 27 controls. RESULTS: We found a significant left-sided reduction in the superior temporal gyrus in both males and females with schizophrenia, which was related to increasing age of onset in the males. The total volume of temporal lobe grey and white matter was also significantly reduced. Although being more marked on the left than the right, the lateralisation for these total grey and white measures (by contrast with the superior temporal gyrus alone) did not attain formal statistical significance. CONCLUSIONS: Confirmation of a lateralised reduction in the superior temporal gyrus, which is differentially related to age of onset according to gender, adds to evidence that the changes in schizophrenia are in systems that are lateralised. The findings implicate language as the relevant function.
机译：背景：克劳先前的报告称精神分裂症的颞角体积左侧增加，意味着左侧组织丢失。目的：阐明精神分裂症的结构性质。方法：测量29例精神分裂症患者和27例对照者的颞叶的颞极和下，中，上颞回回的灰质的体积，以及灰质和白质的总体积。结果：我们发现患有精神分裂症的男性和女性的颞上回的左侧明显减少，这与男性发病年龄的增加有关。颞叶灰色和白色物质的总量也显着减少。尽管这些总的灰色和白色量度（与单独的颞上回相对比）在左侧比在右侧更显眼，但它们并没有获得正式的统计意义。结论：上颞回的侧向减少的确认，与性别的发病年龄不同，增加了证据表明精神分裂症的改变是在侧向系统中。调查结果暗示语言是相关功能。

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