The truth about genetic variation in the serotonin transporter gene and response to stress and medication

Peter McGuffin; Shaza Alsabban; Rudolf Uher

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The truth about genetic variation in the serotonin transporter gene and response to stress and medication

机译：关于血清素转运蛋白基因遗传变异以及对压力和药物反应的真相

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The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.

机译：关于5-羟色胺转运蛋白基因（5-HTTLPR）的启动子中的功能性变体是否影响对逆境和/或抗抑郁药的反应的问题引起了极大的兴趣和争议。文献回顾表明，方法和样本种族的差异使问题变得复杂。如果考虑到这些混杂因素，则5-HTTLPR对5-羟色胺再摄取抑制剂和环境逆境的反应可能有很小的真实影响。

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《The British journal of psychiatry :》 |2011年第6期|共4页
作者
Peter McGuffin; Shaza Alsabban; Rudolf Uher;
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正文语种 eng
中图分类精神病学;
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1. The truth about genetic variation in the serotonin transporter gene and response to stress and medication [J] . Peter McGuffin, Shaza Alsabban, Rudolf Uher The British journal of psychiatry : . 2011,第6期

机译：关于血清素转运蛋白基因遗传变异以及对压力和药物反应的真相
2. Daily stress reactivity and serotonin transporter gene (5-HTTLPR) variation: internalizing responses to everyday stress as a possible transdiagnostic phenotype [J] . Christopher C Conway, George M Slavich, Constance Hammen Biology of Mood & Anxiety Disorders . 2014,第1期

机译：日常应激反应和血清素转运蛋白基因（5-HTTLPR）变异：将对日常应激的反应内化为可能的转诊表型
3. Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans [J] . Eva Kosek, Karin B Jensen, Tina B Lonsdorf, Molecular pain . 2009,第S1期

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机译：血清素基因，激素和侵略内的遗传变异
5. Phenotypic and genetic variation in an Apios americana breeding collection; and characterization of the HD-Zip gene family, involved in abiotic stress responses in Glycine max. [D] . Belamkar, Vikas. 2015

机译：美国Apios育种中的表型和遗传变异； HD-Zip基因家族的克隆和鉴定，参与了甘氨酸非生物胁迫反应。
6. Daily stress reactivity and serotonin transporter gene (5-HTTLPR) variation: internalizing responses to everyday stress as a possible transdiagnostic phenotype [O] . Christopher C Conway, George M Slavich, Constance Hammen 2014

机译：日常应激反应和血清素转运蛋白基因（5-HTTLPR）变异：将对日常应激的内在化作为可能的转诊表型
7. The truth about genetic variation in the serotonin transporter gene and response to stress and medication [O] . McGuffin, Peter, Alsabban, Shaza, Uher, Rudolf 2011

机译：关于血清素转运蛋白基因遗传变异以及对压力和药物反应的真相

The truth about genetic variation in the serotonin transporter gene and response to stress and medication

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