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首页> 外文期刊>The British journal of psychiatry : >Annual high-dose vitamin D3 and mental well-being: randomised controlled trial.
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Annual high-dose vitamin D3 and mental well-being: randomised controlled trial.

机译：年度大剂量维生素D3和心理健康：随机对照试验。

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BACKGROUND: Epidemiological evidence supports a relationship between vitamin D and mental well-being, although evidence from large-scale placebo-controlled intervention trials is lacking. AIMS: To examine if vitamin D supplementation has a beneficial effect on mood in community-dwelling older women; if a single annual large dose of vitamin D has a role in the prevention of depressive symptoms; and if there is an association between serum 25-hydroxyvitamin D levels and mental health. METHOD: A double-blind, randomised, placebo-controlled trial of women aged 70 or older (the Vital D Study: ISRCTN83409867 and ACTR12605000658617). Participants were randomly assigned to receive 500 000 IU vitamin D(3) (cholecalciferol) orally or placebo every autumn/winter for 3-5 consecutive years. The tools utilised at various time points were the General Health Questionnaire, the 12-item Short Form Health Survey, the Patient Global Impression-Improvement scale and the WHO Well-Being Index. Serum 25-hydroxyvitamin D levels were measured in a subset of 102 participants. RESULTS: In this non-clinical population, no significant differences between the vitamin D and placebo groups were detected in any of the measured outcomes of mental health. Serum 25-hydroxyvitamin D levels in the vitamin D group were 41% higher than the placebo group 12 months following their annual dose. Despite this difference, scores from the questionnaires did not differ. Furthermore, there was no interaction between those on antidepressant/anxiety medication at baseline and the treatment groups. CONCLUSIONS: The lack of improvement in indices of mental well-being in the vitamin D group does not support the hypothesis that an annual high dose of vitamin D(3) is a practical intervention to prevent depressive symptoms in older community-dwelling women.
机译：背景：尽管缺乏大规模安慰剂对照干预试验的证据，流行病学证据支持维生素D与心理健康之间的关系。目的：研究补充维生素D是否对社区老年妇女的情绪产生有益影响;每年一次大剂量维生素D是否可预防抑郁症状;血清25-羟基维生素D水平与心理健康之间是否存在关联。方法：一项针对70岁以上女性的双盲，随机，安慰剂对照试验（重要的D研究：ISRCTN83409867和ACTR12605000658617）。参与者被随机分配为每年秋天/冬天口服或连续3-5年接受500 000 IU维生素D（3）（胆钙化醇）或安慰剂。在各个时间点使用的工具是《一般健康调查表》，12个项目的简短健康调查，《患者总体印象改善量表》和《世界卫生组织幸福指数》。在102名参与者的亚组中测量了血清25-羟基维生素D水平。结果：在这一非临床人群中，在任何可衡量的心理健康结局中，维生素D和安慰剂组之间均未发现显着差异。维生素D组的年度剂量后12个月，血清25-羟基维生素D水平比安慰剂组高41％。尽管存在这种差异，但调查问卷的分数没有差异。此外，基线时抗抑郁/焦虑药物治疗者与治疗组之间没有相互作用。结论：维生素D组的心理健康指数缺乏改善，并不支持以下假设：每年高剂量的维生素D（3）是预防老年社区女性抑郁症状的实用干预措施。

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